Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children.
Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children.
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寨卡病毒感染导致小鼠和儿童多种神经功能和行为出现不同程度的缺陷
DOI：
10.1002/advs.201901996
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Zhao Z;Shang Z;Vasconcelos Z;Li C;Jiang Y;Zu S;Zhang J;Wang F;Yao L;Jung JU;Brasil P;Moreira ME;Qin CF;Kerin T;Nielsen-Saines K;Cheng G;Zhang X;Xu Z
寨卡病毒（ZIKV）是一种常见的寨卡病毒性疾病，它与先天性寨卡综合征（Zika syndrome，Zika syndrome）有着密切的关系。孕妇感染ZIKV可能导致儿童出现一系列异常。在巴西的研究中，跟踪了围产期暴露于ZIKV的大型儿童队列，并确定了一系列神经发育异常。同时，证明了当代ZIKV毒株而不是亚洲祖先毒株对小鼠新生儿脑的感染可引起小头畸形和各种异常神经功能。这些缺陷包括社交互动和抑郁症，学习和记忆受损，以及严重的运动缺陷，这些缺陷存在于成年小鼠以及前瞻性的儿童队列中。重要的是，尽管出生后感染的小鼠大脑没有明显的异常大脑结构，但这些小鼠仍然显示出视觉皮层功能，电路组织和经验依赖性可塑性的显著损伤。因此，该研究表明，应特别关注ZIKV感染母亲所生的所有儿童，以筛查儿童期的异常行为和感觉功能。
Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience‐dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.
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DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
双眼输入重合介导小鼠初级视觉皮层的关键期可塑性
影响因子：
5.3
作者：
Chen, Xiao-jing;Rasch, Malte J.;Zhang, Xiao-hui
通讯作者：
Zhang, Xiao-hui
影响因子：
16.2
作者：
Wang, Bor-Shuen;Sarnaik, Rashmi;Cang, Jianhua
通讯作者：
Cang, Jianhua
影响因子：
30.3
作者：
Shan C;Xie X;Muruato AE;Rossi SL;Roundy CM;Azar SR;Yang Y;Tesh RB;Bourne N;Barrett AD;Vasilakis N;Weaver SC;Shi PY
通讯作者：
Shi PY