A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork.
A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork.
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DOI：
10.1016/j.preteyeres.2022.101063
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发表时间：
2022-09
影响因子：
17.8
通讯作者：
Stamer, W. Daniel
中科院分区：
文献类型：
--
作者：
Coulon, Sara J.;Schuman, Joel S.;Du, Yiqin;Fard, Mohammad Reza Bahrani;Ethier, C. Ross;Stamer, W. Daniel
青光眼是全球不可逆性失明的主要原因，需要研究新的，比目前存在的更有效的治疗方案。小梁网（TM）细胞在维持和功能的水外流途径中起着重要的作用，研究发现，有减少的青光眼中的TM细胞。在过去的几十年里，一些报道已经提出用干细胞再生TM作为一种新的治疗选择。干细胞具有自我更新的能力和分化成成体功能细胞的潜力。几种类型的干细胞已在眼再生医学中研究：组织特异性干细胞，胚胎干细胞，诱导多能干细胞和成体间充质干细胞。这些细胞已用于各种青光眼动物模型和离体模型，并已显示出在IOP稳态和TM细胞结构恢复方面的成功。它们还表现出稳定性，在相当长的一段时间内没有严重的副作用。基于目前青光眼TM病理学的知识和现有的关于该组织干细胞再生的文献，我们提出了一项人类临床研究，作为理解这种潜在革命性治疗模式的下一步。保护和替代昏迷眼睛中TM细胞的能力可能会永远改变这一领域。
Glaucoma is the leading cause of global irreversible blindness, necessitating research for new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells play an important role in the maintenance and function of the aqueous outflow pathway, and studies have found that there is decreased cellularity of the TM in glaucoma. Regeneration of the TM with stem cells has been proposed as a novel therapeutic option by several reports over the last few decades. Stem cells have the capacity for self-renewal and the potential to differentiate into adult functional cells. Several types of stem cells have been investigated in ocular regenerative medicine: tissue specific stem cells, embryonic stem cells, induced pluripotent stem cells, and adult mesenchymal stem cells. These cells have been used in various glaucoma animal models and ex vivo models and have shown success in IOP homeostasis and TM cellularity restoration. They have also demonstrated stability without serious side effects for a significant period of time. Based on current knowledge of TM pathology in glaucoma and existing literature regarding stem cell regeneration of this tissue, we propose a human clinical study as the next step in understanding this potentially revolutionary treatment paradigm. The ability to protect and replace TM cells in glaucomatous eyes could change the field forever.
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