Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.
Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.
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DOI：
10.1186/1471-2377-14-13
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发表时间：
2014-01-15
期刊：
影响因子：
2.6
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Mo C;Peng Q;Sui J;Wang J;Deng Y;Xie L;Li T;He Y;Qin X;Li S
据报道，组织蛋白酶D C224T多态性与AD易感性相关。但结果并不一致。本研究旨在评估C224T多态性与AD风险的关系。检索2013年7月更新的PubMed、Embase、Web of Science、b谷歌Scholar和万方电子数据库，确定相关研究。组织蛋白酶D C224T多态性与AD风险的关系通过ORs和95% ci进行评估。meta分析共纳入25项病例对照研究，包括5602例病例和11049例对照。C224T多态性与AD风险之间没有关联，所有研究均纳入meta分析（CT vs. CC: OR = 1.125, 95% CI = 0.974-1.299, P = 0.109; CT + TT vs. CC: OR = 1.136, 95% CI = 0.978-1.320, P = 0.094）。此外，当按种族、发病年龄和APOEϵ4状态分层时，并没有在所有亚组中发现显著的关联。目前的荟萃分析表明，组织蛋白酶D C224T多态性与AD易感性无关。
Cathepsin D C224T polymorphism has been reported to associate with AD susceptibility. But the results were inconsistent. This study aimed to assess the relationship between C224T polymorphism and AD risk. The relevant studies were identified by searching PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated on July 2013. The relationship between Cathepsin D C224T polymorphism and AD risk was evaluated by ORs and 95% CIs. A total of 25 case-control studies including 5,602 cases and 11,049 controls were included in the meta-analysis. There was no association between C224T polymorphism and AD risk with all the studies were pooled in the meta-analysis (CT vs. CC: OR = 1.125, 95% CI = 0.974-1.299, P = 0.109; CT + TT vs. CC: OR = 1.136, 95% CI = 0.978-1.320, P = 0.094). Furthermore, when stratified by ethnicity, age of onset and APOEϵ4 status, significant association did not found in all subgroups. The present meta-analysis suggested that the Cathepsin D C224T polymorphism was not associated with AD susceptibility.
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DOI：
10.3233/jad-2011-101932
发表时间：
2011
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Carrasquillo MM;Belbin O;Hunter TA;Ma L;Bisceglio GD;Zou F;Crook JE;Pankratz VS;Sando SB;Aasly JO;Barcikowska M;Wszolek ZK;Dickson DW;Graff-Radford NR;Petersen RC;Morgan K;Younkin SG
通讯作者：
Younkin SG
影响因子：
--
作者：
Gao, S;Hendrie, HC;Hall, KS
通讯作者：
Hall, KS
影响因子：
2.5
作者：
Bagnoli, S;Nacmias, B;Sorbi, S
通讯作者：
Sorbi, S
影响因子：
4.4
作者：
Mariani, Elena;Seripa, Davide;Mecocci, Patrizia
通讯作者：
Mecocci, Patrizia
影响因子：
2.5
作者：
Bhojak, TJ;DeKosky, ST;Kamboh, MI
通讯作者：
Kamboh, MI