Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.
Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.
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DOI：
10.1016/j.fertnstert.2018.01.039
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发表时间：
2018-06
影响因子：
6.7
通讯作者：
Steiner AZ
中科院分区：
文献类型：
--
作者：
Lyttle Schumacher BM;Jukic AMZ;Steiner AZ
To determine the association between anti-mϋllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies. Prospective cohort study. Community-based cohort. Women (N=533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally. None. Miscarriage, defined as an intrauterine pregnancy loss prior to 20 weeks gestation. After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (Risk Ratio (RR) per unit increase in natural log of AMH= 0.83, 95% CI: 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ≤0.4 ng/ml) miscarried at over twice the rate of women with an AMH ≥ 1ng/mL (HR 2.3; 95% CI 1.3, 4.3). AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.
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