Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study.
Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study.
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DOI：
10.1002/mrm.26579
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发表时间：
2017-03
影响因子：
3.3
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Deng Z;Fan Z;Lee SE;Nguyen C;Xie Y;Pang J;Bi X;Yang Q;Choi BW;Kim JS;Berman D;Chang HJ;Li D
探讨使用相位对比（PC）-MRI测量冠状动脉两侧血压差ΔP的可行性，以无创评估冠状动脉狭窄的功能意义。采用2D-PC-MRI获得的冠状动脉三向速度与Navier-Stokes方程结合计算ΔP。进行重复体模研究以评估流速和ΔP的再现性。比较PC-MRI测量的ΔP（ΔPMR）和压力传感器测量的ΔP（ΔPPT）。在健康对照组（n = 11）中评估冠状动脉血流速度的再现性。对疑似冠心病患者（n = 6）进行了研究，以评估跨冠状动脉狭窄测量ΔPMR的可行性。体模：观察到流速和ΔP测量的良好总体再现性和极好的相关性（ΔPMR vs ΔPPT）：组内相关性（ICC）分别为0.95（Vz）、0.72（Vx）、0.73（Vy）和0.87（ΔPMR），R2 =0.94。人类：观察到冠状动脉血流速度的良好再现性：在心动时相1/2时ICC为0.94/0.95（Vz）、0.76/0.74（Vx）和0.80/0.77（Vy）。与对照组（0.70 ± 0.57 mmHg）相比，患者（6.40 ± 4.43 mmHg）的ΔPMR显著增加（p=0.025）。冠状动脉ΔPMR是可行的。经进一步验证，使用有创测量，ΔPMR有潜力的冠状动脉狭窄的无创评估。
To investigate the feasibility of blood pressure difference measurement, ΔP, across the coronary artery using phase contrast (PC)-MRI for potential noninvasive assessment of the functional significance of coronary artery stenosis. Three-directional velocities in the coronary arteries acquired using 2D-PC-MRI were used with the Navier-Stokes equations to derive ΔP. Repeat phantom studies were performed to assess the reproducibility of flow velocity and ΔP. ΔP derived using PC-MRI (ΔPMR) and that obtained using pressure transducer (ΔPPT) were compared. Reproducibility of coronary flow velocity was assessed in healthy controls (n = 11). Patients with suspected coronary artery disease (n = 6) were studied to evaluate the feasibility of ΔPMR measurement across a coronary stenosis. Phantom: Good overall reproducibility of flow velocity and ΔP measurements and excellent correlation (ΔPMR vs ΔPPT) was observed: intraclass correlation (ICC) of 0.95(Vz), 0.72(Vx), 0.73(Vy), and 0.87(ΔPMR) and R2 =0.94, respectively. Human: Good reproducibility of coronary flow velocity was observed: ICC of 0.94/0.95(Vz), 0.76/0.74(Vx), and 0.80/0.77(Vy) at cardiac phase 1/2. Significant (p=0.025) increase in ΔPMR was observed in patients (6.40 ± 4.43 mmHg) versus controls (0.70 ± 0.57 mmHg). ΔPMR in the coronary arteries is feasible. Upon further validation using the invasive measure, ΔPMR has the potential for noninvasive assessment of coronary artery stenosis.
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影响因子：
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