Correlation between circulating endothelial progenitor cells and serum carcinoembryonic antigen level in colorectal cancer
Correlation between circulating endothelial progenitor cells and serum carcinoembryonic antigen level in colorectal cancer
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结直肠癌循环内皮祖细胞与血清癌胚抗原水平的相关性
DOI：
10.1093/abbs/gmx147
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发表时间：
2018
影响因子：
3.7
通讯作者：
Hongli Liu
中科院分区：
文献类型：
--
作者：
Yuanxiang Li;Jingwen Liu;Zheyan Zhao;Lu Wen;Huili Li;Jinghua Ren;Hongli Liu
循环内皮祖细胞在肿瘤的发生发展中起着重要作用。以往的研究表明，血清癌胚抗原(CEA)水平和外周血循环内皮祖细胞(CEPC)的数量均与肿瘤新生血管生成有关，可用于监测肿瘤的进展、复发、转移和治疗反应。然而，这些生物标记物的临床相关性仍不清楚。采用流式细胞术检测40例结直肠癌患者和17例健康志愿者外周血中cEPC的含量。CEA-RIACT法测定血清CEA水平。结果表明，cEPC水平与疾病分期呈正相关，与年龄、性别无关。此外，血清CEA水平越高的患者cEPC水平越高。这些结果为两个常用生物标志物之间的相关性提供了临床证据。进一步了解血清CEA在cEPC介导的肿瘤血管形成中的作用可能会改善临床结直肠癌的诊断，并为针对肿瘤血管的治疗干预措施的设计提供有用的见解。
Circulating endothelial progenitor cells (cEPCs) play an important role in cancer development. Previous studies showed that serum carcinoembryonic antigen (CEA) levels and the number of circulating endothelial progenitor cells (cEPCs) in the peripheral blood are both involved in tumor neoangiogenesis, and can be used for monitoring tumor progression, recurrence, metastasis, and therapeutic responses. However, the clinical relevance of these biomarkers remains unknown. In this study, 40 colorectal cancer (CRC) patients and 17 healthy volunteers were recruited and the amount of cEPCs in the peripheral blood was measured by flow cytometry. The serum CEA level was determined by CEA-RIACT assay. Results showed that cEPC level positively correlated with the stage of the disease, but not with the age and gender of the patients. Moreover, patients with higher serum CEA levels had higher cEPC levels. These results provide clinical evidence for a correlation between two commonly used biomarkers. Further understanding the role of serum CEA in cEPC-mediated tumor vascularization may improve clinical CRC diagnosis and provide useful insights into the design of therapeutic interventions that target tumor vasculature.
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影响因子：
3.7
作者：
Shinkins B;Nicholson BD;Primrose J;Perera R;James T;Pugh S;Mant D
通讯作者：
Mant D
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
4.8
作者：
Taheri, M;Saragovi, HU;Stanners, CP
通讯作者：
Stanners, CP
DOI：
10.1186/1756-9966-29-27
发表时间：
2010-03-24
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Su Y;Zheng L;Wang Q;Li W;Cai Z;Xiong S;Bao J
通讯作者：
Bao J
影响因子：
2.8
作者：
K. Ramcharan;G. Lip;P. Stonelake;A. Blann
通讯作者：
K. Ramcharan;G. Lip;P. Stonelake;A. Blann