A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection.
A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection.
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DOI：
10.1038/s41541-022-00512-x
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发表时间：
2022-07-25
期刊：
影响因子：
9.2
通讯作者：
中科院分区：
文献类型：
--
作者：
A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated vaccine vector (Modified Vaccinia Ankara, MVA) with the authentic conformation of virus-like particles (VLPs). The vaccine expresses minimal components to generate self-assembling VLPs in the vaccinee: the envelope glycoprotein GP and the matrix protein VP40. Guinea pigs vaccinated with one dose of MVA-VLP-SUDV generated SUDV-specific binding and neutralizing antibody responses as well as Fc-mediated protective effects. These responses were boosted by a second vaccine dose. All vaccinated animals which received either one or two vaccine doses were protected from death and disease symptoms following challenge with a lethal dose of SUDV. These data demonstrate single dose protection and potency of the MVA-VLP platform for use in emergency situations to contain outbreaks.
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影响因子：
3.8
作者：
Mire CE;Geisbert JB;Marzi A;Agans KN;Feldmann H;Geisbert TW
通讯作者：
Geisbert TW
免疫途径定义了疫苗介导的对SIV的保护的多种机制。
影响因子：
82.9
作者：
Ackerman ME;Das J;Pittala S;Broge T;Linde C;Suscovich TJ;Brown EP;Bradley T;Natarajan H;Lin S;Sassic JK;O'Keefe S;Mehta N;Goodman D;Sips M;Weiner JA;Tomaras GD;Haynes BF;Lauffenburger DA;Bailey-Kellogg C;Roederer M;Alter G
通讯作者：
Alter G
影响因子：
4.8
作者：
Wolfe DN;Taylor MJ;Zarrabian AG
通讯作者：
Zarrabian AG
影响因子：
3.7
作者：
Albarino, C. G.;Shoemaker, T.;Stroeher, U.
通讯作者：
Stroeher, U.
DOI：
10.1073/pnas.95.10.5762
发表时间：
1998-05-12
影响因子：
11.1
作者：
Volchkov, VE;Feldmann, H;Klenk, HD
通讯作者：
Klenk, HD