Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus.
Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus.
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DOI：
10.1080/21645515.2020.1741313
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发表时间：
2020-11-01
影响因子：
4.8
通讯作者：
Zarrabian AG
中科院分区：
文献类型：
--
作者：
Wolfe DN;Taylor MJ;Zarrabian AG
2014-2016年西非埃博拉病毒疫情引发了公共和私人合作伙伴的广泛投资，试图减缓疾病传播并控制疫情。这大大加快了针对扎伊尔埃博拉病毒的对策的发展步伐，使疫苗成为有效应对刚果民主共和国最近2018-2019年疫情的一部分。然而，对于针对引起病毒性出血热的丝状病毒科的其他成员的医学对策仍然存在迫切且未满足的需求。为了改善国家和全球对病毒性出血热的准备状态，重新强调开发扎伊尔埃博拉病毒以外的丝状病毒疫苗。在这里，我们讨论了从西非疫情中吸取的教训，以及这些教训如何应用于其他丝状病毒，特别是苏丹埃博拉病毒和马尔堡病毒的候选疫苗的开发。本评论将强调一些关键的产品开发差距，以解决在准备未来的疾病爆发所造成的这些病毒。
The 2014–2016 Ebola virus epidemic in West Africa triggered extensive investments from public and private partners in an attempt to slow the spread of disease and bring the outbreak under control. This significantly accelerated the pace of development of countermeasures against Zaire ebolavirus that enabled vaccines to be a part of an effective response to the most recent 2018–2019 outbreak in the Democratic Republic of the Congo. However, there remain urgent and unmet needs for medical countermeasures against other members of the Filoviridae family that cause viral hemorrhagic fevers. To improve the national and global preparedness posture for viral hemorrhagic fevers, a renewed emphasis is being placed on developing vaccines for filoviruses other than Zaire ebolavirus. Here we discuss lessons learned from the West Africa epidemic and how those lessons apply to the development of vaccine candidates for other filoviruses, specifically Sudan ebolavirus and Marburg virus. This commentary will highlight some of the key product development gaps to address in preparation for future disease outbreaks caused by these viruses.
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影响因子：
168.9
作者：
Kibuuka, Hannah;Berkowitz, Nina M.;Ledgerwood, Julie E.
通讯作者：
Ledgerwood, Julie E.
影响因子：
6.4
作者：
Jones, Steven M.;Stroeher, Ute;Feldmann, Heinz
通讯作者：
Feldmann, Heinz
影响因子：
4.7
作者：
Alfson, Kendra J.;Avena, Laura E.;Griffiths, Anthony
通讯作者：
Griffiths, Anthony
影响因子：
28.3
作者：
Goldstein T;Anthony SJ;Gbakima A;Bird BH;Bangura J;Tremeau-Bravard A;Belaganahalli MN;Wells HL;Dhanota JK;Liang E;Grodus M;Jangra RK;DeJesus VA;Lasso G;Smith BR;Jambai A;Kamara BO;Kamara S;Bangura W;Monagin C;Shapira S;Johnson CK;Saylors K;Rubin EM;Chandran K;Lipkin WI;Mazet JAK
通讯作者：
Mazet JAK
DOI：
10.1093/infdis/jiw209
发表时间：
2016-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Cross RW;Mire CE;Borisevich V;Geisbert JB;Fenton KA;Geisbert TW
通讯作者：
Geisbert TW