Non-equilibrium chromosome looping via molecular slip-links
Non-equilibrium chromosome looping via molecular slip-links
复制标题
通过分子滑动连接的非平衡染色体成环
DOI：
10.1101/095992
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Brackley C
中科院分区：
文献类型：
--
作者：
Brackley C
我们提出了一个模型的基础上扩散滑动的分子滑动链接的染色质环的形成。这些分子模拟了像粘附素这样的分子的行为，粘附素沿着CTCF蛋白，稳定有助于组织基因组的环。通过结合三维布朗动力学模拟和一维精确可解的非平衡模型，我们表明，扩散滑动是足以占强偏见，有利于收敛CTCF介导的染色体环实验观察。我们还发现，多个滑动链接沿着染色质的扩散运动是由一个有趣的棘轮效应，如果滑动链接绑定到染色质在一个首选的“加载网站”纠正。这种紧急的集体行为有利于比单个滑动链接形成的环大得多的环的挤出。
We propose a model for the formation of chromatin loops based on the diffusive sliding of molecular slip links. These mimic the behavior of molecules like cohesin, which, along with the CTCF protein, stabilize loops which contribute to organizing the genome. By combining 3D Brownian dynamics simulations and 1D exactly solvable nonequilibrium models, we show that diffusive sliding is sufficient to account for the strong bias in favor of convergent CTCF-mediated chromosome loops observed experimentally. We also find that the diffusive motion of multiple slip links along chromatin is rectified by an intriguing ratchet effect that arises if slip links bind to the chromatin at a preferred “loading site.” This emergent collective behavior favors the extrusion of loops which are much larger than the ones formed by single slip links.
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影响因子：
8.8
作者：
Stigler J;Çamdere GÖ;Koshland DE;Greene EC
通讯作者：
Greene EC
合作伙伴
DOI：
--
发表时间：
2014
期刊：
影响因子：
--
作者：
Alexandre P. Bazanté;G. Beck;G. D. Bernholdt;G. Beste;GS Denis Bokhan;GC Amy Boone;G. Claudino;G. Gwaltney;GC Werner Györffy;G. Henderson;G. T. Hughes;G. Y. Jin;G. W. Lauderdale;G. D. Magers;G. J. McClellan;G. Melnichuk;G. R. Molt;G. R. Peloquin;A. Perera;G. Pluta;G. Rishi;G. P. Rozyczko;G. Salemi;G. Salter;G. Schweigert;GC Szymon Śmiga;G. J. Sun;G. Taube;G. D. Taylor;G. M. Tobita;Shuai Wang;G. T. Watson;G. Wilson;G. Włoch;G. A. Yau;G. S. Zarrabian;L. Adamowicz;P. Baeck;P. Balková;P. M. Barysz;P. Bracken;P. Byrd;P. I. Cernusak;P. S. Cole;P. Comeau;P. Cory;P. Fau;P. Fitzgerald;P. Flocke;Jan Geertsen;P. Grabowski;P. A. Gregusova;P. G. Gutsev;P. R. Harrison;P. Hino;Y. Hsiao;P. S. Ivanov;P. C. Jamorski;P. T. Kinoshita;PS Anatoli Korkin;P. Kuś;PS Stanislaw Kucharski;P. W. Laidig;P. Lee;P. V. Lotrich;PS Dmitry Lyakh;P. Chang;J. Mei;P. Meissner;P. Musial;P. Noga;PS Marcel Nooijen;P. Oliphant;PS Sourav Pal;P. Piecuch;P. Podeszwa;PS George Purvis;P. L. Redmon;P. M. Rittby;P. Runge;PS Hideo Sekino;P. M. Sekušak;P. Sosa;P. J. Stanton;PS Péter Szalay;PS Krzysztof Szalewicz;P. T. Tsuchiya;P. Varga;PS John Watts;G. Adams;S. Alexander;S. Andrews;S. Baldridge;S. C. Bauschilcher;J. Bellum;S. Bent;S. M. Berman;S. G. Blyholder;S. Boldyrev;S. Boyd;S. E. Brändas;S. F. Brown;S. R. Brown;S. Burke;S. F. Cargnoni;S. Čarsky;S. G. Chan;S. C. Chang;S. Christe;S. Compton;S. Cremer;S. Daniel;S. Bene;S. A. A. Dersi;S. E. Deumens;S. Elguero;S. Ellis;S. G. Fagas;S. Ferris;S. G. Fogarasi;S. J. Franz;S. M. Gordon;S. J. Greer;S. Hamrick;S. M. Head;I. Hubač;S. P. J¢rgensen;S. Jaworski;S. P. Jena;S. Leszczyński;J. Kahn;S. R. Kaiser;S. V. Karasiev;S. Koch;S. Koelling;S. Kraka;S. H. Kroto;S. J. Kwaitkowski;S. J. Lee;S. T. Lee;S. Les;S. Lindh;S. Lipscomb;S. S. Lunnell;S. Mó;S. E. Mccullough;S. M. McKee;S. Mebel;S. Monaghan;S. H. Monkhorst;S. Mukherjee
通讯作者：
S. Mukherjee
DOI：
--
发表时间：
2009
期刊：
影响因子：
--
作者：
S. Majumdar;A. Comtet;J. Randon
通讯作者：
J. Randon
影响因子：
64.5
作者：
Rao SS;Huntley MH;Durand NC;Stamenova EK;Bochkov ID;Robinson JT;Sanborn AL;Machol I;Omer AD;Lander ES;Aiden EL
通讯作者：
Aiden EL
影响因子：
12.3
作者：
Uusküla-Reimand L;Hou H;Samavarchi-Tehrani P;Rudan MV;Liang M;Medina-Rivera A;Mohammed H;Schmidt D;Schwalie P;Young EJ;Reimand J;Hadjur S;Gingras AC;Wilson MD
通讯作者：
Wilson MD