Clinical characterization of hospitalized COVID-19 patients during the second wave of pandemic in the district of Rohrbach, Upper Austria : A single center retrospective study.
Clinical characterization of hospitalized COVID-19 patients during the second wave of pandemic in the district of Rohrbach, Upper Austria : A single center retrospective study.
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DOI：
10.1007/s00508-021-01961-5
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发表时间：
2021-12
影响因子：
2.6
通讯作者：
Aichberger KJ
中科院分区：
文献类型：
--
作者：
Rosenberger K;Pöschl F;Geschev S;Steiner K;Puig S;Röper-Kelmayr J;Aichberger KJ
在2020年11月冠状病毒病2019年(新冠肺炎)大流行第二波高峰期间，据报道，上奥地利罗尔巴赫地区7天来严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)阳性病例的发病率是全球最高的。在这项研究中，我们呈现了2020年10月至2021年2月期间在罗尔巴赫地区唯一的初级保健医院住院的患者中，第二波疫情期间新冠肺炎病例的临床特征。总共有260名患者住院，平均年龄72岁，平均死亡率14.6%，13名患者(5%)被转移到重症监护病房(ICU)。与轻中度患者相比，危重患者(22.7%)年龄较大，通常生活在退休和护理设施中。与轻中度新冠肺炎患者相比，病程严重的患者住院时间明显延长，入院时外周血氧饱和度显著降低，C反应蛋白、降钙素原、乳酸脱氢酶、肌钙蛋白I和D-二聚体水平显著升高。这些实验室参数可能有助于识别病程较重的新冠肺炎患者。总而言之，我们可以表明，年老体弱的人是受新冠肺炎影响最脆弱的群体。住院患者的这一趋势是否会随着大流行的持续、新病毒变异的出现以及几种不同疫苗的可获得性而继续下去，目前尚不清楚，还有待确定。
During the peak of the second wave of the coronavirus disease 2019 (COVID-19) pandemic in November 2020, the district of Rohrbach, Upper Austria, was reported to have had the highest 7‑day incidence of severe acute respiratory syndrome coronavirus‑2 (SARS-CoV-2) positive cases worldwide. In this study, we present the clinical characteristics of COVID-19 cases during the second wave of the pandemic in patients admitted to the only primary care hospital in the district of Rohrbach between October 2020 and February 2021. In total, 260 patients were hospitalized with a mean age of 72 years and a mortality rate of 14.6% and 13 patients (5%) were transferred to the intensive care unit (ICU). Critically ill patients (22.7%) were of older age and often lived in retirement and nursing facilities as compared to mild or moderately ill patients. Patients with a severe disease course showed significantly longer hospitalization, a worse peripheral oxygen saturation on admission and significantly higher levels of C‑reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), troponin I and D‑dimer as compared to mild or moderate COVID-19 cases. These laboratory parameters might help to identify COVID-19 patients with a severe disease course. In conclusion, we could show that older, frail individuals are the most vulnerable group affected by COVID-19. Whether this trend in hospitalized patients continues with the persistence of the pandemic, the emergence of novel virus mutations, and the availability of several different vaccines is presently unclear and remains to be determined.
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