Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network.
Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network.
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DOI：
10.1038/s41467-023-39073-5
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发表时间：
2023-06-09
影响因子：
16.6
通讯作者：
Mysore, Shreesh P.
中科院分区：
文献类型：
--
作者：
Schryver, Hannah M.;Mysore, Shreesh P.
中脑空间注意网络中的抑制性神经元，称为大细胞峡部（Imc），通过感觉运动和注意中枢，即视觉顶盖（OT）控制刺激选择。在这里，我们研究了仓鸮Imc接受野（RFs）的经典和非经典（全局）抑制包围是如何构建的，RFs是Imc计算函数的基本单位。我们发现，对Imc神经元gaba能输入的局灶性、可逆性阻断断开了它们的经典外抑制性包围，但保留了它们的经典抑制性包围。随后，通过配对记录和离子电泳，首先在Imc和OT中空间排列的位点对上，然后在Imc中相互距离的位点对上，我们证明Imc RFs的经典抑制包围来自OT，但它们的经典外抑制包围是在Imc中构建的。这些结果揭示了中脑空间注意回路的关键设计原则，并强调了中脑空间注意回路中竞争相互作用对其运作的关键重要性。Imc是中脑抑制核，对跨空间刺激选择至关重要。作者在仓鸮的实验中发现，Imc神经元的全局抑制环是在Imc内构建的，但它们的经典抑制环是从输入遗传的。
Inhibitory neurons in the midbrain spatial attention network, called isthmi pars magnocellularis (Imc), control stimulus selection by the sensorimotor and attentional hub, the optic tectum (OT). Here, we investigate in the barn owl how classical as well as extraclassical (global) inhibitory surrounds of Imc receptive fields (RFs), fundamental units of Imc computational function, are constructed. We find that focal, reversible blockade of GABAergic input onto Imc neurons disconnects their extraclassical inhibitory surrounds, but leaves intact their classical inhibitory surrounds. Subsequently, with paired recordings and iontophoresis, first at spatially aligned site-pairs in Imc and OT, and then, at mutually distant site-pairs within Imc, we demonstrate that classical inhibitory surrounds of Imc RFs are inherited from OT, but their extraclassical inhibitory surrounds are constructed within Imc. These results reveal key design principles of the midbrain spatial attention circuit and highlight the critical importance of competitive interactions within Imc for its operation. Imc is a midbrain inhibitory nucleus essential for stimulus selection across space. Here, the authors show in the barn owl that global inhibitory surrounds of Imc neurons are constructed within Imc, but their classical inhibitory surrounds are inherited from inputs.
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影响因子：
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作者：
Knudsen EI
通讯作者：
Knudsen EI
影响因子：
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作者：
Gutfreund, Yoram;Knudsen, Eric I.
通讯作者：
Knudsen, Eric I.
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作者：
Mysore, Shreesh P.;Knudsen, Eric I.
通讯作者：
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作者：
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