Restoration of fMRI Decodability Does Not Imply Latent Working Memory States.

Restoration of fMRI Decodability Does Not Imply Latent Working Memory States.
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DOI:
10.1162/jocn_a_01180
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发表时间:
2017-12
影响因子:
3.2
通讯作者:
Bays PM
Bays PM
中科院分区:
医学3区
文献类型:
--
作者:
Schneegans S;Bays PM

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最近的成像研究挑战了工作记忆是由持续的神经活动介导的流行观点。使用机器学习方法来重建记忆内容,这些研究发现,以前减少的表征可以通过回顾性提示或其他形式的刺激来恢复。这些发现被解释为活动沉默的工作记忆状态,可以重新激活依赖于任务的需求的证据。在这里,我们测试这一结论的有效性,制定一个神经过程模型的工作记忆的基础上持续的活动,并使用该模型来模拟一个空间回忆任务与回溯。模拟再现的行为和功能磁共振成像结果,以前采取的证据为潜在的国家,特别是恢复空间重建质量的信息提示。我们的研究结果表明,成像信号的可解码性的恢复并没有为活动沉默的工作记忆状态提供令人信服的证据。
Recent imaging studies have challenged the prevailing view that working memory is mediated by sustained neural activity. Using machine learning methods to reconstruct memory content, these studies found that previously diminished representations can be restored by retrospective cueing or other forms of stimulation. These findings have been interpreted as evidence for an activity-silent working memory state that can be reactivated dependent on task demands. Here, we test the validity of this conclusion by formulating a neural process model of working memory based on sustained activity and using this model to emulate a spatial recall task with retrocueing. The simulation reproduces both behavioral and fMRI results previously taken as evidence for latent states, in particular the restoration of spatial reconstruction quality following an informative cue. Our results demonstrate that recovery of the decodability of an imaging signal does not provide compelling evidence for an activity-silent working memory state.
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