Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine.
Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine.
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DOI：
10.1002/jor.22516
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发表时间：
2014-02
影响因子：
2.8
通讯作者：
Lotz, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Fields, Aaron J.;Rodriguez Sanz, David;Gary, Kaitlyn N.;Liebenberg, Ellen C.;Lotz, Jeffrey C.
终板软骨完整性对脊柱健康至关重要，并且可能因生化成分恶化而受损。然而，终板生化成分和生物力学性能之间的定量关系是不可用的。使用从人腰椎（6个供体，年龄51-67岁）中收获的终板软骨，我们发现终板生化成分对其平衡拉伸性能有显着影响，并且终板损伤的存在与成分-功能关系的减弱有关。我们发现平衡拉伸模量（5.9±5.7 MPa）与胶原含量（559±147 μg/mg干重，r2=0.35）和胶原/GAG比值（6.0±2.1，r2=0.58）显著相关。考虑到邻近软骨的损伤状态，改善了后者的相关性（r2=0.77），并表明具有邻近损伤（如裂隙和撕脱）的样本具有降低的模量-胶原蛋白/GAG关系（p=0.02）。准线性粘弹性松弛特性（C，t1和t2）没有相关的生化组成。我们的结论是，减少基质量降低人体终板软骨的平衡拉伸模量和生化成分的特征，是独立的基质量，即基质质量相关的特性，也可能是重要的。
Endplate cartilage integrity is critical to spine health and is presumably impaired by deterioration in biochemical composition. Yet, quantitative relationships between endplate biochemical composition and biomechanical properties are unavailable. Using endplate cartilage harvested from human lumbar spines (six donors, ages 51–67 years) we showed that endplate biochemical composition has a significant influence on its equilibrium tensile properties and that the presence of endplate damage associates with a diminished composition–function relationship. We found that the equilibrium tensile modulus (5.9±5.7 MPa) correlated significantly with collagen content (559±147 μg/mg dry weight, r2=0.35) and with the collagen/GAG ratio (6.0±2.1, r2=0.58). Accounting for the damage status of the adjacent cartilage improved the latter correlation (r2=0.77) and indicated that samples with adjacent damage such as fissures and avulsions had a diminished modulus–collagen/GAG relationship (p=0.02). Quasi-linear viscoelastic relaxation properties (C, t1, and t2) did not correlate with biochemical composition. We conclude that reduced matrix quantity decreases the equilibrium tensile modulus of human endplate cartilage and that characteristics of biochemical composition that are independent of matrix quantity, that is, characteristics related to matrix quality, may also be important.
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影响因子：
2.8
作者：
Benneker, LM;Heini, PF;Ito, K
通讯作者：
Ito, K
DOI：
10.1016/0304-4165(86)90306-5
发表时间：
1986-09-04
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
FARNDALE, RW;BUTTLE, DJ;BARRETT, AJ
通讯作者：
BARRETT, AJ
影响因子：
2.8
作者：
Moon, Sung M.;Yoder, Jonathon H.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.
影响因子：
3
作者：
Ohtori, S;Inoue, G;Takahashi, K
通讯作者：
Takahashi, K
影响因子：
2.8
作者：
Elliott, DM;Guilak, F;Setton, LA
通讯作者：
Setton, LA