Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.
Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.
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DOI：
10.1016/j.canlet.2013.09.008
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发表时间：
2015-01-01
期刊：
影响因子：
9.7
通讯作者：
Martin, Olga A.
中科院分区：
文献类型：
--
作者：
Sprung, Carl N.;Ivashkevich, Alesia;Forrester, Helen B.;Redon, Christophe E.;Georgakilas, Alexandros;Martin, Olga A.
关键词：
自从长泽和利特尔首次描述了培养细胞中的一种现象以来，在过去的20年里，人们报道了一系列辐射诱导的非靶向效应，这种现象后来被称为“旁观者效应”。这些非靶向效应包括与放射治疗相关的非内窥镜效应，即器官或组织的变化发生在远离受照射区域的地方。随着时间的推移，非靶向效应的范围不断扩大，现在包括了许多类型的外源性和内源性应激源，这些应激源可以诱导全身的遗传毒性反应，包括被广泛研究的肿瘤微环境。在这里，我们讨论了在非靶向细胞和组织中诱导DNA损伤的过程和因素，并强调了不同应激源引起的全身效应调节的相似性。
A spectrum of radiation-induced non-targeted effects has been reported during the last two decades since Nagasawa and Little first described a phenomenon in cultured cells that was later called the “bystander effect”. These non-targeted effects include radiotherapy-related abscopal effects, where changes in organs or tissues occur distant from the irradiated region. The spectrum of non-targeted effects continue to broaden over time and now embrace many types of exogenous and endogenous stressors that induce a systemic genotoxic response including a widely studied tumor microenvironment. Here we discuss processes and factors leading to DNA damage induction in non-targeted cells and tissues and highlight similarities in the regulation of systemic effects caused by different stressors.
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影响因子：
8.8
作者：
Belyakov OV;Malcolmson AM;Folkard M;Prise KM;Michael BD
通讯作者：
Michael BD
影响因子：
15.3
作者：
BISCHOFF, SC;KRIEGER, M;DAHINDEN, CA
通讯作者：
DAHINDEN, CA
影响因子：
6.4
作者：
Chaudhry, MA
通讯作者：
Chaudhry, MA
DOI：
10.1073/pnas.0505020102
发表时间：
2005-10-04
影响因子：
11.1
作者：
Belyakov, OV;Mitchell, SA;Brenner, DJ
通讯作者：
Brenner, DJ
影响因子：
2.6
作者：
Calveley, VL;Khan, MA;Hill, RP
通讯作者：
Hill, RP