Clinical and serologic responses to acellular pertussis vaccine in infants and young children.
Clinical and serologic responses to acellular pertussis vaccine in infants and young children.
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婴儿和幼儿对无细胞百日咳疫苗的临床和血清学反应。
DOI：
10.1001/archpedi.1987.04460090026016
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发表时间：
1987
影响因子：
--
通讯作者：
S. Vernon
中科院分区：
文献类型：
--
作者：
E. Anderson;R. Belshe;J. Bartram;M. Gurwith;P. Hung;M. Levner;S. Vernon
我们给三组20名儿童（4 - 6岁，17 - 21个月和5 - 9个月）接种了含无细胞（淋巴细胞增生促进因子和丝状血凝素）百日咳疫苗的白喉、破伤风和百日咳（DTP）疫苗。所有儿童对疫苗的耐受性都很好；未发生禁止进一步免疫的反应。年龄较大的儿童明显比年幼的儿童有更多的局部（红肿）和全身（发烧或烦躁）反应。在接种疫苗一个月后，两个较大年龄组中80%至90%的儿童对百白破抗原的抗体滴度增加了四倍或更多。所有儿童接种疫苗后破伤风、白喉抗体浓度均大于0.01 IU/mL。对淋巴细胞增多促进因子和丝状血凝素的血清学反应随年龄的变化而变化；年龄较大的儿童比年龄较小的儿童明显增加了4倍或更多。根据以前的研究报告，无细胞百日咳百白破疫苗在幼儿中具有抗原性，并且比标准的全细胞百日咳百白破疫苗的反应性更低。
We administered diphtheria, tetanus, and pertussis (DTP) vaccine containing acellular (lymphocytosis promoting factor and filamentous hemagglutinin) pertussis vaccine to three groups of 20 children each (4 to 6 years, 17 to 21 months, and 5 to 9 months of age). All the children tolerated the vaccine well; no reactions occurred that contraindicated further immunization. Older children had significantly more local (redness or swelling) and systemic (fever or fretfulness) reactions than younger children. Eighty percent to 90% of the children in the two older age groups had fourfold or greater increases in antibody titers to DTP antigens one month after vaccination. The postvaccine concentrations of antibody to tetanus and diphtheria were greater than 0.01 IU/mL in all children. Serologic responses to lymphocytosis promoting factor and filamentous hemagglutinin varied with age; significantly more older children than younger children had four-fold or greater increases. Acellular pertussis DTP vaccine was antigenic in young children and was less reactogenic than standard whole cell DTP vaccine according to rates reported in previous studies.
百日咳博德特氏菌对人呼吸道上皮细胞的粘附。
DOI：
10.1093/infdis/148.1.125
发表时间：
1983
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Tuomanen,EI;Hendley,JO
通讯作者：
Hendley,JO