No association of cortical amyloid load and EEG connectivity in older people with subjective memory complaints.
No association of cortical amyloid load and EEG connectivity in older people with subjective memory complaints.
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DOI：
10.1016/j.nicl.2017.10.031
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
INSIGHT-preAD study group
中科院分区：
文献类型：
--
作者：
Teipel S;Bakardjian H;Gonzalez-Escamilla G;Cavedo E;Weschke S;Dyrba M;Grothe MJ;Potier MC;Habert MO;Dubois B;Hampel H;INSIGHT-preAD study group
在健康老龄化以及AD的临床前和临床阶段的静息态EEG研究中已经观察到皮质网络功能连接的变化。然而，很少有信息存在于主观记忆投诉的人脑电图连接和皮质淀粉样蛋白负荷之间的关联。在这里，我们确定了全局皮质淀粉样蛋白负荷的关联，如通过florbetapir-PET测量的，与基于静息状态EEG数据的相位滞后指数的α和β频段的功能连接，在318个认知正常的人，年龄在70-85岁之间，来自INSIGHT-preAD队列的主观记忆投诉。在整个组中，我们没有发现任何频率带中的全局淀粉样蛋白负荷和相位滞后指数之间的任何显著关联。专门评估淀粉样蛋白阳性参与者的亚组，我们发现功能连接增强，α中的整体淀粉样蛋白负荷更高，β频带减少。在淀粉样蛋白阴性的参与者中，较高的淀粉样蛋白负荷与低α带中较低的连通性相关。然而，在控制多重比较后，这些相关性未能达到显著性。淀粉样蛋白对功能连接没有强烈的影响可能代表了一种选择效应，只有当淀粉样蛋白积累不损害皮质功能连接时，个体才能保持在认知正常组中。一个验证性研究，在主观记忆抱怨（SMC）。淀粉样蛋白与SMC的功能连接无关。淀粉样蛋白对认知的影响与SMC的功能连接无关。功能性连接的变化可能会跟随淀粉样蛋白负荷与时间延迟。
Changes in functional connectivity of cortical networks have been observed in resting-state EEG studies in healthy aging as well as preclinical and clinical stages of AD. Little information, however, exists on associations between EEG connectivity and cortical amyloid load in people with subjective memory complaints. Here, we determined the association of global cortical amyloid load, as measured by florbetapir-PET, with functional connectivity based on the phase-lag index of resting state EEG data for alpha and beta frequency bands in 318 cognitively normal individuals aged 70–85 years with subjective memory complaints from the INSIGHT-preAD cohort. Within the entire group we did not find any significant associations between global amyloid load and phase-lag index in any frequency band. Assessing exclusively the subgroup of amyloid-positive participants, we found enhancement of functional connectivity with higher global amyloid load in the alpha and a reduction in the beta frequency bands. In the amyloid-negative participants, higher amyloid load was associated with lower connectivity in the low alpha band. However, these correlations failed to reach significance after controlling for multiple comparisons. The absence of a strong amyloid effect on functional connectivity may represent a selection effect, where individuals remain in the cognitively normal group only if amyloid accumulation does not impair cortical functional connectivity. A confirmatory study in subjective memory complainers (SMC) is presented. Amyloid is not associated with functional connectivity in SMC. Effects of amyloid on cognition are independent of functional connectivity in SMC. Functional connectivity changes may follow amyloid load with a temporal delay.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.9
作者：
Fastenau, PS;Denburg, NL;Hufford, BJ
通讯作者：
Hufford, BJ