Blood-Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders.
Blood-Brain Barrier Disruption and Its Involvement in Neurodevelopmental and Neurodegenerative Disorders.
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DOI：
10.3390/ijms232315271
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发表时间：
2022-12-03
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
血脑屏障（BBB）是一个高度专业化的和动态的隔室，它调节从血液中摄取的分子和溶质。维持健康的血脑屏障支持疾病预防的相关性以及影响血脑屏障功能的主要病理机制将在本次审查中详细介绍。屏障破坏是神经退行性疾病（如肌萎缩性侧索硬化症）和神经发育疾病（包括自闭症谱系障碍）中的常见方面。在整个审查，条件改变血脑屏障在生命的最早和最后阶段将进行讨论，揭示涉及的共同因素。由于屏障在保护大脑免受外源性成分和外源性物质影响方面的作用，药物递送穿过BBB是具有挑战性的。基于血脑屏障特性的潜在疗法，如分子特洛伊木马等，将被审查，以及创新的治疗方法，如干细胞疗法。此外，由于微生物群对大脑正常功能的影响，将讨论微生物群调节策略。最后，未来的研究方向强调，以解决目前的文献差距，强调的想法，神经发育和神经退行性病变的共同疗法存在。
The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which regulates the uptake of molecules and solutes from the blood. The relevance of the maintenance of a healthy BBB underpinning disease prevention as well as the main pathomechanisms affecting BBB function will be detailed in this review. Barrier disruption is a common aspect in both neurodegenerative diseases, such as amyotrophic lateral sclerosis, and neurodevelopmental diseases, including autism spectrum disorders. Throughout this review, conditions altering the BBB during the earliest and latest stages of life will be discussed, revealing common factors involved. Due to the barrier’s role in protecting the brain from exogenous components and xenobiotics, drug delivery across the BBB is challenging. Potential therapies based on the BBB properties as molecular Trojan horses, among others, will be reviewed, as well as innovative treatments such as stem cell therapies. Additionally, due to the microbiome influence on the normal function of the brain, microflora modulation strategies will be discussed. Finally, future research directions are highlighted to address the current gaps in the literature, emphasizing the idea that common therapies for both neurodevelopmental and neurodegenerative pathologies exist.
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影响因子：
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