Danhong injection: A modulator for Golgi structural stability after cerebral ischemia-reperfusion injury.
Danhong injection: A modulator for Golgi structural stability after cerebral ischemia-reperfusion injury.
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DOI：
10.3969/j.issn.1673-5374.2013.25.005
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发表时间：
2013-09-05
影响因子：
6.1
通讯作者：
Lu W
中科院分区：
文献类型：
--
作者：
Wang Y;Hu Z;Lu W
采用线栓法建立脑缺血再灌注模型，造模前给大鼠腹腔注射丹红注射液8 mL/kg，每天1次。再灌注后6、24、48、72小时收获大鼠脑组织。免疫组化染色显示脑缺血再灌注后转化生长因子-β1表达增加，高尔基体基质蛋白GM130表达减少。丹红注射液显着上调转化生长因子-β1和GM130的表达，且表达水平在再灌注后7天达到峰值。脑缺血再灌注后7天，未治疗组大鼠高尔基体形态发生破坏，而丹红注射液干预后未观察到高尔基体形态破坏。这些实验结果表明，丹红注射液能够上调转化生长因子-β1和GM130的表达，维持高尔基体的稳定性，从而对脑缺血再灌注后的大鼠发挥神经保护作用。
The cerebral ischemia-reperfusion model was established using the suture occlusion method, and rats were intraperitoneally given 8 mL/kg Danhong injection once a day prior to model establishment. Rat brain tissues were harvested at 6, 24, 48, 72 hours after reperfusion. Immunohistochemical staining showed that transforming growth factor-β1 expression increased, while Golgi matrix protein GM130 expression decreased after cerebral ischemia-reperfusion. Danhong injection was shown to significantly up-regulate the expression of transforming growth factor-β1 and GM130, and expression levels peaked at 7 days after reperfusion. At 7 days after cerebral ischemia-reperfusion, Golgi morphology was damaged in untreated rats, while Golgi morphology breakage was not observed after intervention with Danhong injection. These experimental findings indicate that Danhong injection can up-regulate the expression of transforming growth factor-β1 and GM130, and maintain Golgi stability, thus playing a neuroprotective role in rats after cerebral ischemia-reperfusion.
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