Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study.
Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study.
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结直肠肿瘤发生过程中肠道微生物群和血浆炎症因子的变化：病例对照研究
DOI：
10.1186/s12866-018-1232-6
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发表时间：
2018-08-29
期刊：
影响因子：
4.2
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Zhang Y;Yu X;Yu E;Wang N;Cai Q;Shuai Q;Yan F;Jiang L;Wang H;Liu J;Chen Y;Li Z;Jiang Q
结直肠癌（colorectal cancer，CRC）是一种常见的胃肠道恶性肿瘤.在中国，CRC是第五大最常见的癌症。绝大多数CRC病例是散发性的，并且随着腺瘤-癌序列而演变。越来越多的证据表明，肠道微生物群和炎症在CRC的发展中起着重要作用，尽管研究结果并不完全一致。在本研究中，我们调查了CRC相关细菌和血浆炎症因子的变化及其相互关系的基础上，从中国汉族病例对照研究的数据。我们包括130初步诊断CRC患者，88晚期结直肠腺瘤患者（A-CRA），62例良性肠息肉和130 controls.ResultsFecal微生物群的组成，获得使用16 S核糖体DNA（16 S rDNA）测序。PCOA分析显示四个研究组之间的微生物群结构差异（P =0.001，Unweighted Unifrac）。通过两步统计方法选择了24种CRC相关细菌，并在这些微生物中观察到显著相关性。CRC相关细菌随肿瘤恶性程度而变化。血浆C-反应蛋白（CRP）和可溶性肿瘤坏死因子II（sTNFR-II）在四个研究组之间显示出显着差异，并随着腺瘤-癌序列的增加而增加。CRP和sTNFR-II与几个CRC相关微生物的相关性也explored. ConclusionsCRC相关物种和血浆炎症因子往往改变沿着腺瘤癌序列。几种CRC相关细菌与CRP和sTNFR-II相关。肠道微生物组和炎症可能逐渐形成与CRC发展相关的微环境。
BackgroundColorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC is the 5th most commonly diagnosed cancer. The vast majority of CRC cases are sporadic and evolve with the adenoma-carcinoma sequence. There is mounting evidence indicating that gut microbiota and inflammation play important roles in the development of CRC although study results are not entirely consistent. In the current study, we investigated the changes in the CRC-associated bacteria and plasma inflammatory factors and their relationships based on data from a case-control study of Han Chinese. We included 130 initially diagnosed CRC patients, 88 advanced colorectal adenoma patients (A-CRA), 62 patients with benign intestinal polyps and 130 controls.ResultsFecal microbiota composition was obtained using 16S ribosomal DNA (16S rDNA) sequencing. PCOA analysis showed structural differences in microbiota among the four study groups (P =0.001, Unweighted Unifrac). Twenty-four CRC-associated bacteria were selected by a two-step statistical method and significant correlations were observed within these microbes. CRC-associated bacteria were found to change with the degree of malignancy. Plasma C-reactive protein (CRP) and soluble tumor necrosis factor II (sTNFR-II) displayed significant differences among the four study groups and increased with adenoma-carcinoma sequence. The correlations of CRP and sTNFR-II with several CRC-associated microbes were also explored.ConclusionsCRC-associated species and plasma inflammatory factors tended to change along the adenoma-carcinoma sequence. Several CRC-associated bacteria were correlated with CRP and sTNFR-II. It is likely that gut microbiome and inflammation gradually form a microenvironment that is associated with CRC development.
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影响因子：
5.2
作者：
Engels C;Ruscheweyh HJ;Beerenwinkel N;Lacroix C;Schwab C
通讯作者：
Schwab C
影响因子：
10.5
作者：
Brennan CA;Garrett WS
通讯作者：
Garrett WS
影响因子：
24.5
作者：
Flemer B;Lynch DB;Brown JM;Jeffery IB;Ryan FJ;Claesson MJ;O'Riordain M;Shanahan F;O'Toole PW
通讯作者：
O'Toole PW
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
影响因子：
64.8
作者：
Grivennikov, Sergei I.;Wang, Kepeng;Mucida, Daniel;Stewart, C. Andrew;Schnabl, Bernd;Jauch, Dominik;Taniguchi, Koji;Yu, Guann-Yi;Oesterreicher, Christoph H.;Hung, Kenneth E.;Datz, Christian;Feng, Ying;Fearon, Eric R.;Oukka, Mohamed;Tessarollo, Lino;Coppola, Vincenzo;Yarovinsky, Felix;Cheroutre, Hilde;Eckmann, Lars;Trinchieri, Giorgio;Karin, Michael
通讯作者：
Karin, Michael