Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy.
Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy.
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DOI：
10.1186/s13075-023-03169-6
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发表时间：
2023-10-04
影响因子：
4.9
通讯作者：
中科院分区：
文献类型：
--
作者：
While many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this improvement or worsening. In our unique RA pregnancy cohort that includes a pre-pregnancy baseline, we have examined pre-pregnancy gene co-expression networks to identify differences between women with RA who subsequently improve during pregnancy and those who worsen. Blood samples were collected before pregnancy (T0) from 19 women with RA and 13 healthy women enrolled in our prospective pregnancy cohort. RA improvement/worsening between T0 and 3rd trimester was assessed by changes in the Clinical Disease Activity Index (CDAI). Pre-pregnancy expression profiles were examined by RNA sequencing and differential gene expression analysis. Weighted gene co-expression network analysis (WGCNA) was used to identify co-expression modules correlated with the improvement/worsening of RA during pregnancy and to assess their functional relevance. Of the 19 women with RA, 14 improved during pregnancy (RAimproved) while 5 worsened (RAworsened). At the T0 baseline, however, the mean CDAI was similar between the two groups. WGCNA identified one co-expression module related to B cell function that was significantly correlated with the worsening of RA during pregnancy and was significantly enriched in genes differentially expressed between the RAimproved and RAworsened groups. A neutrophil-related expression signature was also identified in the RAimproved group at the T0 baseline. The pre-pregnancy gene expression signatures identified represent potential biomarkers to predict the subsequent improvement/worsening of RA during pregnancy, which has important implications for the personalized treatment of RA during pregnancy. The online version contains supplementary material available at 10.1186/s13075-023-03169-6.
影响因子：
3.8
作者：
Hao Y;Wu W;Shi F;Dalmolin RJ;Yan M;Tian F;Chen X;Chen G;Cao W
通讯作者：
Cao W
影响因子：
4.3
作者：
Tschumper RC;Hoelzinger DB;Walters DK;Davila JI;Osborne CA;Jelinek DF
通讯作者：
Jelinek DF
影响因子：
1.8
作者：
Henning AN;Green D;Baumann R;Grandinetti P;Highfill SL;Zhou H;De Giorgi V
通讯作者：
De Giorgi V