Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives.
Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives.
复制标题
DOI：
10.1093/femsre/fuu001
复制
发表时间：
2015-01
影响因子：
11.3
通讯作者：
Pelicic V
中科院分区：
文献类型：
--
作者：
Berry JL;Pelicic V
原核生物已经设计出复杂的表面纳米机器，使它们能够在地球上殖民，甚至在极端环境中茁壮成长。由IV型菌毛蛋白组成的丝状体机制，与从运动性到电导性的一系列惊人特性相关，可以说是最普遍的，因为在大多数已知的原核生物物种中发现了致力于其生物发生的独特蛋白质。几十年的研究，从IV型皮利开始，然后是细菌和古细菌中的各种相关系统，已经概述了这些纳米机器的共同分子和结构基础。使用IV型皮利作为一个范例，我们将在这篇评论中强调这组丝状结构的共同点和关键的生物学差异。使用IV型皮利作为一个范例，我们审查共同的遗传，结构和机械特征（许多）以及差异（很少）的异常广泛和功能多样的原核纳米机器组成的IV型菌毛。使用IV型皮利作为一个范例，我们审查共同的遗传，结构和机械特征（许多）以及差异（很少）的异常广泛和功能多样的原核纳米机器组成的IV型菌毛。
Prokaryotes have engineered sophisticated surface nanomachines that have allowed them to colonize Earth and thrive even in extreme environments. Filamentous machineries composed of type IV pilins, which are associated with an amazing array of properties ranging from motility to electric conductance, are arguably the most widespread since distinctive proteins dedicated to their biogenesis are found in most known species of prokaryotes. Several decades of investigations, starting with type IV pili and then a variety of related systems both in bacteria and archaea, have outlined common molecular and structural bases for these nanomachines. Using type IV pili as a paradigm, we will highlight in this review common aspects and key biological differences of this group of filamentous structures. Using type IV pili as a paradigm, we review common genetic, structural and mechanistic features (many) as well as differences (few) of the exceptionally widespread and functionally versatile prokaryotic nano-machines composed of type IV pilins. Using type IV pili as a paradigm, we review common genetic, structural and mechanistic features (many) as well as differences (few) of the exceptionally widespread and functionally versatile prokaryotic nano-machines composed of type IV pilins.
登录
查看更多内容
影响因子：
3.2
作者：
Aukema, KG;Kron, EM;Forest, KT
通讯作者：
Forest, KT
影响因子：
3.1
作者：
Akahane, K;Sakai, D;Komano, T
通讯作者：
Komano, T
影响因子：
3.2
作者：
Alm, RA;Bodero, AJ;Mattick, JS
通讯作者：
Mattick, JS
影响因子：
5.6
作者：
Ayers, M.;Sampaleanu, L. M.;Burrows, L. L.
通讯作者：
Burrows, L. L.
影响因子：
3.6
作者：
Bardy, SL;Jarrell, KF
通讯作者：
Jarrell, KF