Disuse-induced muscle wasting.
Disuse-induced muscle wasting.
复制标题
DOI：
10.1016/j.biocel.2013.06.011
复制
发表时间：
2013-10
影响因子：
4
通讯作者：
Bodine, Sue C.
中科院分区：
文献类型：
--
作者：
Bodine, Sue C.
骨骼肌质量的损失经常发生在临床环境中，以响应关节固定和卧床休息，并由卸载和不活动的组合引起。废用性萎缩可能会影响每个人的一生，尤其是老年人。目前还没有很好的治疗废用性肌肉萎缩的方法，部分原因是缺乏对诱导和维持肌肉萎缩的细胞和分子机制的了解。我们目前对废用性萎缩的理解来自于对动物和人类各种模型（关节固定、后肢卸载、卧床休息、脊髓损伤）的研究。在卸载条件下，人们普遍认为蛋白质合成减少，然而，蛋白质降解的作用，特别是在人类中，是有争议的。这篇综述将探讨目前对废用条件下肌肉损失的分子和细胞调节机制的理解，讨论动物和人类文献之间的相似性和争议领域。
Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint immobilization and bed rest, and is induced by a combination of unloading and inactivity. Disuse-induced atrophy will likely affect every person in his or her lifetime, and can be debilitating especially in the elderly. Currently there are no good therapies to treat disuse-induced muscle atrophy, in part, due to a lack of understanding of the cellular and molecular mechanisms responsible for the induction and maintenance of muscle atrophy. Our current understanding of disuse atrophy comes from the investigation of a variety of models (joint immobilization, hindlimb unloading, bed rest, spinal cord injury) in both animals and humans. Under conditions of unloading, it is widely accepted that there is a decrease in protein synthesis, however, the role of protein degradation, especially in humans, is debated. This review will examine the current understanding of the molecular and cellular mechanisms regulating muscle loss under disuse conditions, discussing the similarities and areas of dispute between the animal and human literature.
登录
查看更多内容
影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
氨基酸和胰岛素对人类肌肉中信号传导，泛素连接酶和蛋白质更新的作用之间的分离。
DOI：
10.1152/ajpendo.90411.2008
发表时间：
2008-09
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
--
作者：
Greenhaff PL;Karagounis LG;Peirce N;Simpson EJ;Hazell M;Layfield R;Wackerhage H;Smith K;Atherton P;Selby A;Rennie MJ
通讯作者：
Rennie MJ
影响因子：
4.8
作者：
Ebert, Scott M.;Dyle, Michael C.;Adams, Christopher M.
通讯作者：
Adams, Christopher M.
影响因子：
5.5
作者：
Brocca, Lorenza;Cannavino, Jessica;Pellegrino, Maria Antonietta
通讯作者：
Pellegrino, Maria Antonietta
影响因子：
5.5
作者：
Glover, Elisa I.;Phillips, Stuart M.;Rennie, Michael J.
通讯作者：
Rennie, Michael J.