Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise.
Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise.
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运动后弓形 NPY/AgRP 和 POMC 神经元的细胞和突触重组。
DOI：
10.1016/j.molmet.2018.08.011
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发表时间：
2018-12
影响因子：
8.1
通讯作者：
Williams KW
中科院分区：
文献类型：
--
作者：
He Z;Gao Y;Alhadeff AL;Castorena CM;Huang Y;Lieu L;Afrin S;Sun J;Betley JN;Guo H;Williams KW
Hypothalamic Pro-opiomelanocortin (POMC) and Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) neurons are critical nodes of a circuit within the brain that sense key metabolic cues as well as regulate metabolism. Importantly, these neurons retain an innate ability to rapidly reorganize synaptic inputs and electrophysiological properties in response to metabolic state. While the cellular properties of these neurons have been investigated in the context of obesity, much less is known about the effects of exercise training. In order to further investigate this issue, we utilized neuron-specific transgenic mouse models to identify POMC and NPY/AgRP neurons for patch-clamp electrophysiology experiments. Using whole-cell patch-clamp electrophysiology, we found exercise depolarized and increased firing rate of arcuate POMC neurons. The increased excitability of POMC neurons was concomitant with increased excitatory inputs to these neurons. In agreement with recent work suggesting leptin plays an important role in the synaptic (re)organization of POMC neurons, POMC neurons which express leptin receptors were more sensitive to exercise-induced changes in biophysical properties. Opposite to effects observed in POMC neurons, NPY neurons were shunted toward inhibition following exercise. Together, these data support a rapid reorganization of synaptic inputs and biophysical properties in response to exercise, which may facilitate adaptations to altered energy balance and glucose metabolism. Exercise inhibited arcuate NPY neurons. Exercise activated arcuate POMC neurons. Leptin receptor expressing POMC neurons are much more sensitive to response to exercise. Exercise effects are transient, lasting only hours for NPY, while sustainable for days in POMC neurons.
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影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
影响因子：
7.7
作者：
Castorena CM;Arias EB;Sharma N;Cartee GD
通讯作者：
Cartee GD
影响因子：
7.7
作者：
BOGARDUS, C;RAVUSSIN, E;SIMS, EAH
通讯作者：
SIMS, EAH
DOI：
10.1152/ajpendo.1995.268.3.e375
发表时间：
1995-03-01
影响因子：
5.1
作者：
COGGAN, AR;SWANSON, SC;KIEN, CL
通讯作者：
KIEN, CL
影响因子：
25
作者：
Horvath, TL
通讯作者：
Horvath, TL