Assessing animal affect: an automated and self-initiated judgement bias task based on natural investigative behaviour.
Assessing animal affect: an automated and self-initiated judgement bias task based on natural investigative behaviour.
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DOI：
10.1038/s41598-018-30571-x
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发表时间：
2018-08-17
影响因子：
4.6
通讯作者：
Mendl M
中科院分区：
文献类型：
--
作者：
Jones S;Neville V;Higgs L;Paul ES;Dayan P;Robinson ESJ;Mendl M
评估动物情感的科学方法，特别是情感效价（积极或消极），使我们能够评估动物福利和旨在改善福祉的3R改进的有效性。判断偏差任务测量效价;然而，任务培训可能是漫长的和/或需要大量的时间从研究人员。在这里，我们开发了一个自动化和自我发起的判断偏见的任务，利用大鼠的自然调查行为。老鼠将鼻子插入食物槽中开始试验。然后，他们听到一个音调，并学会要么停留2秒以获得食物奖励，要么迅速撤退以避免喷气。哪种偶然性适用由两种不同的音调来表示。判断偏差是通过对中间模糊音调的反应来衡量的。在两个实验中，我们发现大鼠学习任务的时间比其他自动化变体少，如预期的那样概括了模糊音调的反应，自我启动4-5次试验/分钟，并且可以重复测试。情感操作在预测的方向上产生主效应趋势，尽管不局限于模糊的音调，因此需要进一步的结构验证。我们还发现，语气词配对和强化或不强化的歧义试验可以影响反应的歧义。这一可翻译的任务应该有助于更广泛地采用判断偏差测试。
Scientific methods for assessing animal affect, especially affective valence (positivity or negativity), allow us to evaluate animal welfare and the effectiveness of 3Rs Refinements designed to improve wellbeing. Judgement bias tasks measure valence; however, task-training may be lengthy and/or require significant time from researchers. Here we develop an automated and self-initiated judgement bias task for rats which capitalises on their natural investigative behaviour. Rats insert their noses into a food trough to start trials. They then hear a tone and learn either to stay for 2 s to receive a food reward or to withdraw promptly to avoid an air-puff. Which contingency applies is signalled by two different tones. Judgement bias is measured by responses to intermediate ambiguous tones. In two experiments we show that rats learn the task in fewer sessions than other automated variants, generalise responses across ambiguous tones as expected, self-initiate 4–5 trials/min, and can be tested repeatedly. Affect manipulations generate main effect trends in the predicted directions, although not localised to ambiguous tones, so further construct validation is required. We also find that tone-reinforcer pairings and reinforcement or non-reinforcement of ambiguous trials can affect responses to ambiguity. This translatable task should facilitate more widespread uptake of judgement bias testing.
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影响因子：
2.3
作者：
Duepjan, Sandra;Stracke, Jenny;Puppe, Birger
通讯作者：
Puppe, Birger
影响因子：
7.6
作者：
Enkel, Thomas;Gholizadeh, Donya;Vollmayr, Barbara
通讯作者：
Vollmayr, Barbara
影响因子：
2.5
作者：
Brydges, Nichola M.;Leach, Matthew;Bateson, Melissa
通讯作者：
Bateson, Melissa
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.4
作者：
Anderson, Michael H.;Munafo, Marcus R.;Robinson, Emma S. J.
通讯作者：
Robinson, Emma S. J.