Development of certified reference materials for electrolytes in human serum (GBW09124-09126)
Development of certified reference materials for electrolytes in human serum (GBW09124-09126)
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人血清电解质标准物质的研制（GBW09124-09126）
DOI：
10.1007/s00216-017-0287-9
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发表时间：
2017-03
影响因子：
4.3
通讯作者：
Li Hongmei
中科院分区：
文献类型：
--
作者：
Feng Liuxing;Wang Jun;Cui Yanjie;Shi Naijie;Li Haifeng;Li Hongmei
开发了相对低、中和高浓度的三种参比物质，用于分析人血清中电解质（K、Ca、Na、Mg、Cl和Li）的质量分数。通过向正常人血清中加入高纯度氯化物盐制备参比物质。三个水平的浓度范围在正常人血清的±20%以内。结果表明，重复分析14个单位足以证明这些候选参比物质的均匀性。在40 ℃下1周的短期稳定性试验和14个月的长期稳定性试验中，统计结果也显示无显著趋势。六种元素的认证方法包括同位素稀释电感耦合等离子体质谱法（ID-ICP-MS）、电感耦合等离子体发射光谱法（ICP-OES）、原子吸收光谱法（AAS）、离子色谱法（IC）和离子选择电极法（伊势）。通过在一些国家计量机构之间进行国际比较，验证了认证方法。通过考虑分析方法、均匀性和稳定性的不确定度，估计了属性值的组合相对标准不确定度。各元素的扩展不确定度范围为2.2%~ 3.9%。有证标准物质主要用于校准和验证临床分析中测定人血清或血浆中电解质的方法。图摘要人血清中钾、钙、镁、钠、氯、锂标准物质（GBW 09124 -09126）
Three reference materials, at relatively low, middle, and high concentrations, were developed for analysis of the mass fractions of electrolytes (K, Ca, Na, Mg, Cl, and Li) in human serum. The reference materials were prepared by adding high purity chloride salts to normal human serum. The concentration range of the three levels is within ±20% of normal human serum. It was shown that 14 units with duplicate analysis is enough to demonstrate the homogeneity of these candidate reference materials. The statistical results also showed no significant trends in both short-term stability test for 1 week at 40 °C and long-term stability test for 14 months. The certification methods of the six elements include isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS), inductively coupled plasma optical emission spectroscopy (ICP-OES), atomic absorption spectroscopy (AAS), ion chromatography (IC), and ion-selective electrode (ISE). The certification methods were validated by international comparisons among a number of national metrology institutes (NMIs). The combined relative standard uncertainties of the property values were estimated by considering the uncertainties of the analytical methods, homogeneity, and stability. The range of the expanded uncertainties of all the elements is from 2.2% to 3.9%. The certified reference materials (CRMs) are primarily intended for use in the calibration and validation of procedures in clinical analysis for the determination of electrolytes in human serum or plasma.Graphical AbstractCertified reference materials for K, Ca, Mg, Na, Cl and Li in human serum (GBW09124-09126)
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DOI：
10.1039/9781847559302
发表时间：
2002-05
期刊：
--
影响因子：
--
作者：
P. Bedson
通讯作者：
P. Bedson
影响因子：
3.4
作者：
A. R. Date;M. Stuart
通讯作者：
A. R. Date;M. Stuart
影响因子：
2.2
作者：
Barbagallo, Romina P.;Boley, Nick;Thomas, Annette
通讯作者：
Thomas, Annette
DOI：
10.1515/cclm.1989.27.1.33
发表时间：
1989
期刊：
--
影响因子：
--
作者：
W. Külpmann;D. Ruschke;J. Büttner;K. Paschen
通讯作者：
W. Külpmann;D. Ruschke;J. Büttner;K. Paschen
影响因子：
2.9
作者：
Pereira Barbosa, Jose Tiago;Moreira Santos, Clarissa Marques;Moraes Flores, Erico Marlon
通讯作者：
Moraes Flores, Erico Marlon