Compete or Coexist? Why the Same Mechanisms of Symmetry Breaking Can Yield Distinct Outcomes.
Compete or Coexist? Why the Same Mechanisms of Symmetry Breaking Can Yield Distinct Outcomes.
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作者：
Goryachev AB;Leda M
细胞形态发生受基于密集蛋白质簇的破坏性出现的预模式控制。因此，一簇活性GTdR Cdc42标记了面包酵母中新生芽的位点。一个重要的生物学问题是，哪些机制控制模式最大值（斑点）的数量，从而控制新生细胞结构的数量。不同风格的理论模型似乎给出了不同的预测。虽然经典的图灵方案导致一系列稳定共存的多个结构，质量守恒模型预测形成一个单一的点，出现通过贪婪的竞争模式之间的最大共同的分子资源。这场竞争的结果和动力学都具有重要的生物学意义，但仍缺乏探索。最近的理论分析在很大程度上解决了这些问题，但其结果尚未得到广泛的生物界的充分赞赏。保持数学仪器和行话到最低限度，我们回顾这些分析的主要结论，其生物学意义铭记在心。专注于小GTP酶模式形成的具体例子，我们推测的功能的图案化机制，绕过竞争，有利于形成多个共存的结构，并将它们与利用竞争，形成独特的细胞结构的机制进行对比。
Cellular morphogenesis is governed by the prepattern based on the symmetry-breaking emergence of dense protein clusters. Thus, a cluster of active GTPase Cdc42 marks the site of nascent bud in the baker’s yeast. An important biological question is which mechanisms control the number of pattern maxima (spots) and, thus, the number of nascent cellular structures. Distinct flavors of theoretical models seem to suggest different predictions. While the classical Turing scenario leads to an array of stably coexisting multiple structures, mass-conserved models predict formation of a single spot that emerges via the greedy competition between the pattern maxima for the common molecular resources. Both the outcome and the kinetics of this competition are of significant biological importance but remained poorly explored. Recent theoretical analyses largely addressed these questions, but their results have not yet been fully appreciated by the broad biological community. Keeping mathematical apparatus and jargon to the minimum, we review the main conclusions of these analyses with their biological implications in mind. Focusing on the specific example of pattern formation by small GTPases, we speculate on the features of the patterning mechanisms that bypass competition and favor formation of multiple coexisting structures and contrast them with those of the mechanisms that harness competition to form unique cellular structures.
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DOI：
10.1387/ijdb.072493rb
发表时间：
2009
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Baker RE;Schnell S;Maini PK
通讯作者：
Maini PK
影响因子：
19.6
作者：
Gross, Peter;Kumar, K. Vijay;Grill, Stephan W.
通讯作者：
Grill, Stephan W.
影响因子：
56.9
作者：
HARTWELL, LH;CULOTTI, J;REID, BJ
通讯作者：
REID, BJ
DOI：
10.1073/pnas.182370299
发表时间：
2002-09-17
影响因子：
11.1
作者：
Caviston, JP;Tcheperegine, SE;Bi, E
通讯作者：
Bi, E
影响因子：
4.3
作者：
Chiou, Jian-Geng;Ramirez, Samuel A.;Lew, Daniel J.
通讯作者：
Lew, Daniel J.