Defecatory Function Studies Using the Fecobionics Device Are Repeatable.
Defecatory Function Studies Using the Fecobionics Device Are Repeatable.
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DOI：
10.1007/s10620-023-07889-2
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发表时间：
2023-06
影响因子：
3.1
通讯作者：
Gregersen H
中科院分区：
文献类型：
--
作者：
Lo KM;Sun D;Chen SC;Leung WW;Wong C;Mak T;Ng S;Futaba K;Gregersen H
使用已建立的评估肛门直肠功能的生理和临床技术进行肛门直肠研究的可重复性的数据有限。 Fecobionics 是一种新型多传感器模拟粪便，通过集成当前测试中的元素来提供数据。我们评估了 Fecobionics 研究数据库，以确定进行了多少次重复研究。从总共 260 项 Fecobionics 研究中，确定了 19 名使用大致相同的方案和原型进行重复研究的受试者。使用 Bland Altman 图评估关键压力和弯曲参数并分析重复性。此外，还计算了个体间和个体内的变异系数（CV）。重复研究的15名受试者（5F/10M）为正常受试者，3名是大便失禁患者，1名受试者患有慢性便秘。主要分析是对正常受试者队列进行的。 11 个参数的偏差位于置信区间内，而 2 个参数的偏差稍稍超出置信区间。弯曲角度的个体间 CV 最低 (10.1–10.7)，压力参数的个体间 CV 最低，介于 16.3 和 51.6 之间。个体内部 CV 大约是个体间 CV 的一半，从 9.7 到 27.6。来自正常受试者的所有数据均在先前定义的正常范围内。 Fecobionics 数据显示出可接受的重复性，几乎所有参数的偏差均在置信限内。个体内CV远低于个体间CV。有必要进行专门的大规模研究来评估年龄、性别和疾病对可重复性的影响以及技术之间的比较。
Only limited data exist on repeatability of anorectal studies with the established physiological and clinical technologies for assessment of anorectal function. Fecobionics is a new multi-sensor simulated feces that provide data by integrating elements from current tests. We assessed the database of Fecobionics studies to determine how many repeated studies were done. From a total of 260 Fecobionics studies, 19 subjects with repeated studies using approximately the same protocol and prototype were identified. Key pressure and bending parameters were assessed and the repeatability analyzed using Bland Altman plots. Furthermore, the inter- and intra-individual coefficient of variation (CV) were computed. Fifteen subjects (5F/10M) with repeated studies were normal subjects, three were patients with fecal incontinence and one subject suffered from chronic constipation. The main analysis was conducted on the cohort of normal subjects. The bias for 11 parameters were within the confidence interval whereas two were slightly outside. The interindividual CV was lowest for the bend angle (10.1–10.7) and between 16.3 and 51.6 for the pressure parameters. The intra-individual CVs were approximately half of the inter-individual CVs, spanning from 9.7 to 27.6. All data from normal subjects were within previously defined normality. The Fecobionics data showed acceptable repeatability with bias within the confidence limits for almost all parameters. The intra-individual CV was much lower than the inter-individual CV. Dedicated large scale studies are warranted to evaluate the influence of age, sex and disease on repeatability as well as comparing between technologies.
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影响因子：
29.4
作者：
Rao, Satish S. C.;Bharucha, Adil E.;Wald, Arnold
通讯作者：
Wald, Arnold
影响因子：
2.4
作者：
GIBBONS, CP;BANNISTER, JJ;READ, NW
通讯作者：
READ, NW
影响因子：
3.5
作者：
Gosling, Jonathan;Plumb, Andrew;Emmanuel, Anton, V
通讯作者：
Emmanuel, Anton, V
影响因子：
3.3
作者：
Chen, S. -C.;Futaba, K.;Gregersen, H.
通讯作者：
Gregersen, H.
影响因子：
9.6
作者：
ROGERS, J;LAURBERG, S;SWASH, M
通讯作者：
SWASH, M