Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data.
Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data.
复制标题
DOI：
10.1016/j.ajog.2011.12.003
复制
发表时间：
2012-02
影响因子：
9.8
通讯作者：
Hassan SS
中科院分区：
文献类型：
--
作者：
Romero R;Nicolaides K;Conde-Agudelo A;Tabor A;O'Brien JM;Cetingoz E;Da Fonseca E;Creasy GW;Klein K;Rode L;Soma-Pillay P;Fusey S;Cam C;Alfirevic Z;Hassan SS
To determine whether the use of vaginal progesterone in asymptomatic women with a sonographic short cervix in the mid-trimester reduces the risk of preterm birth and improves neonatal morbidity and mortality. Individual patient data meta-analysis of randomized controlled trials. Five trials of high quality were included with a total of 775 women and 827 infants. Treatment with vaginal progesterone was associated with a significant reduction in the rate of preterm birth <33 weeks (RR 0.58, 95% CI 0.42–0.80), <35 weeks (RR 0.69, 95% CI 0.55–0.88) and <28 weeks (RR 0.50, 95% CI 0.30–0.81), respiratory distress syndrome (RR 0.48, 95% CI 0.30–0.76), composite neonatal morbidity and mortality (RR 0.57, 95% CI 0.40–0.81), birth weight <1500 g (RR 0.55, 95% CI 0.38–0.80), admission to NICU (RR 0.75, 95% CI 0.59–0.94), and requirement for mechanical ventilation (RR 0.66, 95% CI 0.44–0.98). There were no significant differences between the vaginal progesterone and placebo groups in the rate of adverse maternal events or congenital anomalies. Vaginal progesterone administration to asymptomatic women with a sonographic short cervix reduces the risk of preterm birth and neonatal morbidity and mortality.
登录
查看更多内容
影响因子：
9.8
作者：
Althuisius, SM;Dekker, GA;Hummel, P
通讯作者：
Hummel, P
影响因子：
9.8
作者：
Cahill AG;Odibo AO;Caughey AB;Stamilio DM;Hassan SS;Macones GA;Romero R
通讯作者：
Romero R
影响因子：
5.8
作者：
Andersson, Stefan;Minjarez, Debra;Word, R. Ann
通讯作者：
Word, R. Ann
影响因子：
7.1
作者：
Celik, E.;To, M.;Nicolaides, K. H.
通讯作者：
Nicolaides, K. H.
影响因子：
2
作者：
Berlin, JA;Santanna, J;Feldman, HI
通讯作者：
Feldman, HI