Phase reduction and phase-based optimal control for biological systems: a tutorial

Phase reduction and phase-based optimal control for biological systems: a tutorial
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生物系统的相还原和基于相的最优控制:教程

DOI:
10.1007/s00422-018-0780-z
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发表时间:
2019
影响因子:
1.9
通讯作者:
Moehlis, Jeff
Moehlis, Jeff
中科院分区:
工程技术3区
文献类型:
--
作者:
Monga, Bharat;Wilson, Dan;Matchen, Tim;Moehlis, Jeff

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分析非线性振荡器的一个强有力的技术是严格简化为相位模型,用一个单一的变量描述相对于某个参考状态的振荡相位。最近提出了一个模拟相位减少系统的稳定不动点,和相位减少周期轨道最近已扩展到考虑横向和高阶项。本教程给出了一个统一的处理,这样的阶段减少技术,并说明其使用通过数学和生物的例子。它还涵盖了使用相位减少设计控制算法,最佳地改变系统的属性,如振荡的相位。举例说明了神经和心脏系统的控制技术。
A powerful technique for the analysis of nonlinear oscillators is the rigorous reduction to phase models, with a single variable describing the phase of the oscillation with respect to some reference state. An analog to phase reduction has recently been proposed for systems with a stable fixed point, and phase reduction for periodic orbits has recently been extended to take into account transverse directions and higher-order terms. This tutorial gives a unified treatment of such phase reduction techniques and illustrates their use through mathematical and biological examples. It also covers the use of phase reduction for designing control algorithms which optimally change properties of the system, such as the phase of the oscillation. The control techniques are illustrated for example neural and cardiac systems.
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