Measuring acute changes in adrenergic nerve activity of the heart in the living animal.

Measuring acute changes in adrenergic nerve activity of the heart in the living animal.
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测量活体动物心脏肾上腺素能神经活动的急性变化。

DOI:
10.1016/0002-8703(91)90671-4
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发表时间:
1991
影响因子:
4.8
通讯作者:
Johnson,J
Johnson,J
中科院分区:
医学2区
文献类型:
--
作者:
Sisson,JC;Bolgos,G;Johnson,J

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心脏肾上腺素能神经元功能的变化可能是动物适应生理应激和疾病的重要指标。心脏去甲肾上腺素 (NE) 的损失率被认为与 NE 分泌和肾上腺素能功能成正比。在大鼠心脏中,育亨宾诱导 3 H-NE 和 125 I-间碘苄基胍(MIBG)(NE 的功能类似物)损失率几乎相同的增加。可乐定诱导 3 H-NE 损失率降低,这也与 125 I-MIBG 的损失率相似。在狗的心脏中,可以从外部测量药物引起的 123 I-MIBG 损失率的增加和减少;这些值与在大鼠心脏中获得的 125 I-MIBG 的值相似。因此,可以在活体心脏中测量肾上腺素能神经元活动的急剧变化。该方法适用于人类确定肾上腺素能系统响应挑衅挑战的能力。
Changes in the function of the adrenergic neurons of the heart may be important indicators of the adaptations of an animal to physiologic stress and disease. Rates of loss of norepinephrine (NE) from the heart were considered to be proportional to NE secretion and to adrenergic function. In rat hearts, yohimbine induced almost identical increases in rates of loss of3H-NE and of125I-metaiodobenzylguanidine (MIBG), a functional analog of NE. Clonidine induced decreases in rates of loss of3H-NE that were also mimicked by those of125I-MIBG. In the dog heart, pharmacologically-induced increases and decreases in rates of loss of123I-MIBG could be measured externally; these values were similar to those obtained for125I-MIBG in the rat heart. Thus acute changes in the adrenergic neuron activity can be measured in the living heart. The method is applicable to man in determining the capacity of the adrenergic system to respond to provocative challenges.
DOI: 10.1152/jappl.1986.61.3.896
发表时间: 1986-09-01
影响因子: 3.3
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DOI: --
发表时间: 1963
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