Changes in the aortic wall oxygen tensions of hypertensive rabbits. Hypertension and aortic wall oxygen.
Changes in the aortic wall oxygen tensions of hypertensive rabbits. Hypertension and aortic wall oxygen.
复制标题
高血压兔主动脉壁氧张力的变化。
DOI：
10.1161/01.hyp.19.1.33
复制
发表时间：
1992
期刊：
影响因子：
8.3
通讯作者：
D. Knighton
中科院分区：
文献类型：
--
作者：
S. Santilli;V. Fiegel;D. Knighton
高血压是动脉粥样硬化的已知危险因素。我们假设高血压导致动脉壁缺氧，从而导致动脉粥样硬化病变的形成。因此，我们研究了高血压对兔主动脉经动脉壁氧梯度的影响。通过单侧肾切除和对侧肾动脉狭窄来产生高血压兔。在兔子高血压后14-16周（短期高血压）和56-58周（长期高血压）使用氧微电极测量肾下主动脉的经动脉壁氧梯度。经动脉壁氧梯度在各组之间显示出显着差异。与长期高血压组和对照组相比，短期高血压导致动脉壁外部 30% 的氧张力显着升高，动脉壁显着变薄。与短期高血压组和对照组相比，长期高血压导致动脉壁内侧40%的氧分压显着降低，动脉壁显着增厚。尽管三组的动脉血氧分压或动脉粥样硬化病变形成的视觉证据没有差异，但仍注意到这些变化。这些发现表明高血压改变了经动脉壁氧梯度。这种改变的经动脉壁氧梯度可能有助于动脉粥样硬化病变的形成。
Hypertension is a known risk factor for atherosclerosis. We hypothesize that hypertension causes artery wall hypoxia that contributes to the formation of atherosclerotic lesions. Therefore, we examined the effect of hypertension on the transarterial wall oxygen gradient of the rabbit aorta. Hypertensive rabbits were created by unilateral nephrectomy and contralateral renal artery narrowing. Transarterial wall oxygen gradients of the infrarenal aorta were measured using an oxygen microelectrode 14-16 weeks (short-term hypertension) and 56-58 weeks (long-term hypertension) after the rabbits were made hypertensive. The transarterial wall oxygen gradients showed significant differences among the groups. Short-term hypertension caused significantly higher oxygen tensions in the outer 30% of the artery wall and significant thinning of the artery wall when compared with long-term hypertension and control groups. Long-term hypertension caused significantly lower oxygen tensions in the inner 40% of the artery wall and significant thickening of the artery wall when compared with short-term hypertension and control groups. These changes were noted despite no difference in the partial pressure of oxygen in arterial blood or visual evidence of atherosclerotic lesion formation in the three groups. These findings suggest that hypertension alters the transarterial wall oxygen gradient. This altered transarterial wall oxygen gradient may contribute to the formation of atherosclerotic lesions.
影响因子：
56.9
作者：
KNIGHTON, DR;HUNT, TK;BANDA, MJ
通讯作者：
BANDA, MJ