Polygenic predisposition, sleep duration, and depression: evidence from a prospective population-based cohort.
Polygenic predisposition, sleep duration, and depression: evidence from a prospective population-based cohort.
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DOI：
10.1038/s41398-023-02622-z
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发表时间：
2023-10-20
影响因子：
6.8
通讯作者：
Ajnakina, Olesya
中科院分区：
文献类型：
--
作者：
Hamilton, Odessa S.;Steptoe, Andrew;Ajnakina, Olesya
睡眠时间不佳和抑郁经常同时发生。短睡眠和长睡眠通常被认为是抑郁症的症状，但越来越多的文献表明它们可能是前驱症状。虽然每个过程都代表着一个相互影响的过程，但它们之间的方向性仍不清楚。使用多基因评分（PGS），我们研究了与次优睡眠持续时间和抑郁症有关的前瞻性方向。年龄≥50岁的男性和女性参与者是从英国老龄化纵向研究（ELSA）中招募的。使用英国生物银行队列的汇总统计数据计算睡眠持续时间、短睡眠和长睡眠的 PGS。睡眠持续时间分为短睡眠（“≤5小时”）、最佳睡眠（“>5至<9小时”）和长睡眠（“≥9小时”），在基线和平均8年随访期间进行测量。在基线和平均 8 年随访中也确定了亚临床抑郁症（流行病学研究中心抑郁量表 [≥4 分，共 7 分]）。短睡眠的 PGS 增加一个标准差与抑郁症发病几率增加 14% 相关（95% CI = 1.03–1.25，p = 0.008）。然而，睡眠持续时间（OR = 0.92，95% CI = 0.84–1.00，p = 0.053）和睡眠时间长（OR = 0.97，95% CI = 0.89–1.06，p = 0.544）的PGS与随访期间出现抑郁症。同一时期，抑郁症的 PGS 与总睡眠时间、短睡眠或长睡眠无关。平均 8 年期间，短睡眠的多基因倾向与抑郁症的发病相关。然而，抑郁症的多基因易感性与总体睡眠时间、短睡眠或长睡眠无关，这表明抑郁症与老年人随后出现的次优睡眠时间之间的关系存在不同的机制。
Suboptimal sleep durations and depression frequently cooccur. Short-sleep and long-sleep are commonly thought of as symptoms of depression, but a growing literature suggests that they may be prodromal. While each represents a process of mutual influence, the directionality between them remains unclear. Using polygenic scores (PGS), we investigate the prospective direction involved in suboptimal sleep durations and depression. Male and female participants, aged ≥50, were recruited from the English Longitudinal Study of Ageing (ELSA). PGS for sleep duration, short-sleep, and long-sleep were calculated using summary statistics data from the UK Biobank cohort. Sleep duration, categorised into short-sleep (“≤5 h”), optimal-sleep (“>5 to <9 h”), and long-sleep (“≥9 h”), was measured at baseline and across an average 8-year follow-up. Subclinical depression (Centre for Epidemiological Studies Depression Scale [≥4 of 7]) was also ascertained at baseline and across an average 8-year follow-up. One standard deviation increase in PGS for short-sleep was associated with 14% higher odds of depression onset (95% CI = 1.03–1.25, p = 0.008). However, PGS for sleep duration (OR = 0.92, 95% CI = 0.84–1.00, p = 0.053) and long-sleep (OR = 0.97, 95% CI = 0.89–1.06, p = 0.544) were not associated with depression onset during follow-up. During the same period, PGS for depression was not associated with overall sleep duration, short-sleep, or long-sleep. Polygenic predisposition to short-sleep was associated with depression onset over an average 8-year period. However, polygenic predisposition to depression was not associated with overall sleep duration, short-sleep or long-sleep, suggesting different mechanisms underlie the relationship between depression and the subsequent onset of suboptimal sleep durations in older adults.
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影响因子：
2.1
作者：
Dudbridge F;Pashayan N;Yang J
通讯作者：
Yang J
影响因子：
30.8
作者：
Das, Sayantan;Forer, Lukas;Schoenherr, Sebastian;Sidore, Carlo;Locke, Adam E.;Kwong, Alan;Vrieze, Scott I.;Chew, Emily Y.;Levy, Shawn;McGue, Matt;Schlessinger, David;Stambolian, Dwight;Loh, Po-Ru;Iacono, William G.;Swaroop, Anand;Scott, Laura J.;Cucca, Francesco;Kronenberg, Florian;Boehnke, Michael;Abecasis, Goncalo R.;Fuchsberger, Christian
通讯作者：
Fuchsberger, Christian
影响因子：
9.9
作者：
Huang J;Zuber V;Matthews PM;Elliott P;Tzoulaki J;Dehghan A
通讯作者：
Dehghan A
DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
5.6
作者：
Ohayon, MM;Carskadon, MA;Vitiello, MV
通讯作者：
Vitiello, MV