Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons
Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons
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尼古丁对甲基苯丙胺引起的感觉运动门控损伤的治疗潜力：苍白球被盖神经元的参与
DOI：
10.1007/s00213-009-1651-z
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发表时间：
2009
影响因子：
3.4
通讯作者：
Kiyofumi Yamada
中科院分区：
文献类型：
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作者：
H. Mizoguchi;S. Arai;H. Koike;D. Ibi;H. Kamei;T. Nabeshima;Hyoung‐Chun Kim;K. Takuma;Kiyofumi Yamada
我们之前已经发现，甲基苯丙胺（METH）诱导的脉冲前抑制（PPI）的破坏与pallidotegmental神经元的功能受损有关，而pallidotegmental神经元通过激活小鼠桥脚被盖神经元中的γ -氨基丁酸B型受体，在惊吓反射的PPI中起着至关重要的作用。目的研究尼古丁对甲基苯丙胺诱导的惊吓反射PPI损伤的影响，该损伤集中在功能失调的苍白质神经元和神经系统上。结果尼古丁（0.15 ~ 0.5 mg/kg）可改善急性冰毒诱导的PPI缺陷，尼古丁的改善作用可被烟碱受体拮抗剂甲基莱卡乌碱和二氢β-红血碱所拮抗。急性甲基苯丙胺诱导的PPI破坏伴随着侧白球（LGP）中c-Fos表达的抑制以及其在桥脑网状核（PnC）尾端的诱导。尼古丁诱导的甲基苯丙胺处理小鼠PPI缺陷的改善伴随着LGP和PnC中c-Fos表达变化的基础水平逆转。结论尼古丁对甲基苯丙胺所致PPI损伤有明显的改善作用，其作用机制可能与被白质神经元的正常化有关。
IntroductionWe have previously found that a disruption to prepulse inhibiton (PPI) induced by methamphetamine (METH) is associated with impaired functioning of pallidotegmental neurons, which play a crucial role in PPI of the startle reflex, through the activation of gamma-aminobutyric acid type B receptors in pedunculopontine tegmental neurons in mice.ObjectivesHere, we examined the effect of nicotine on METH-induced impairment of PPI of the startle reflex focusing on dysfunctional pallidotegmental neurons and the neural system.ResultsNicotine (0.15–0.5 mg/kg) ameliorated the deficit in PPI induced by acute METH, and the ameliorating effect of nicotine was antagonized by nicotinic receptor antagonists such as methyllycaconitine and dihydro-β-erythroidine. The acute METH-induced disruption of PPI was accompanied by suppression of c-Fos expression in the lateral globus pallidus (LGP) as well as its induction in the caudal pontine reticular nucleus (PnC) in mice subjected to the PPI test. Nicotine-induced amelioration of PPI deficits in METH-treated mice was accompanied by a reversal of the changes in c-Fos expression in both the LGP and PnC to the basal level.ConclusionsNicotine is effective in ameliorating the impairment of PPI caused by METH, which may be associated with normalization of the pallidotegmental neurons.
影响因子：
--
作者：
N. Swerdlow;D. Braff;N. Taaid;M. Geyer
通讯作者：
N. Swerdlow;D. Braff;N. Taaid;M. Geyer
精神分裂症患者吸烟使听觉生理正常化。
DOI：
10.1176/ajp.150.12.1856
发表时间：
1993
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Adler,LE;Hoffer,LD;Wiser,A;Freedman,R
通讯作者：
Freedman,R