Hybrid soft-lithography/laser machined microchips for the parallel generation of droplets.
Hybrid soft-lithography/laser machined microchips for the parallel generation of droplets.
复制标题
DOI：
10.1039/c3lc50979f
复制
发表时间：
2013-12-21
期刊：
影响因子：
6.1
通讯作者：
Issadore D
中科院分区：
文献类型：
--
作者：
Muluneh M;Issadore D
已经开发了微流体芯片以产生液滴和微粒，其具有使用常规方法不可能的对尺寸、形状和组成的控制。然而，由于微尺度器件固有的有限吞吐量，对于实际应用而言，扩大生产仍然是一个挑战。为了解决这个问题，我们已经开发了一个独立的微芯片，集成了许多（N = 512）微尺度液滴制造商。这种3 × 3 cm 2的PDMS微芯片由32 × 16个流动聚焦液滴制造器的二维阵列、连接它们的流动通道网络以及只有两个输入和一个输出组成。该技术的关键创新是软光刻和直接激光微加工的混合使用。微尺度分辨率的软光刻被用来制造流动聚焦液滴制造器，可以产生小而精确定义的液滴。深刻（h ≤ 500 μm）激光加工通道用于为每个液滴制造器提供油相、水相和输出通道。雕刻通道的低流体动力学阻力确保每个液滴制造器以相同的流速驱动，以形成高度均匀的液滴。为了证明这种方法的实用性，在十六烷中以8 × 1和32 × 16两种几何形状生成水滴（d ≤ 80 μm）。
Microfluidic chips have been developed to generate droplets and microparticles with control over size, shape, and composition not possible using conventional methods. However, it has remained a challenge to scale-up production for practical applications due to the inherently limited throughput of micro-scale devices. To address this problem, we have developed a self-contained microchip that integrates many (N = 512) micro-scale droplet makers. This 3 × 3 cm2 PDMS microchip consists of a two-dimensional array of 32 × 16 flow-focusing droplet makers, a network of flow channels that connect them, and only two inputs and one output. The key innovation of this technology is the hybrid use of both soft-lithography and direct laser-micromachining. The microscale resolution of soft lithography is used to fabricate flow-focusing droplet makers that can produce small and precisely defined droplets. Deeply engraved (h ≈ 500 μm) laser-machined channels are utilized to supply each of the droplet makers with its oil phase, aqueous phase, and access to an output channel. The engraved channels' low hydrodynamic resistance ensures that each droplet maker is driven with the same flow rates for highly uniform droplet formation.To demonstrate the utility of this approach, water droplets (d ≈ 80 μm) were generated in hexadecane on both 8 × 1 and 32 × 16 geometries.
登录
查看更多内容
影响因子：
6.7
作者：
Koziej, Dorota;Floryan, Caspar;Weitz, David A.
通讯作者：
Weitz, David A.
影响因子：
24.2
作者：
Shah, Rhutesh K.;Shum, Ho Cheung;Weitz, David A.
通讯作者：
Weitz, David A.
影响因子：
29.4
作者：
Nisisako, Takasi;Torii, Toru;Takizawa, Yoichi
通讯作者：
Takizawa, Yoichi
影响因子：
15
作者：
Chen, Delai;Love, Kevin T.;Anderson, Daniel G.
通讯作者：
Anderson, Daniel G.
影响因子：
6.1
作者：
Hatch, Andrew C.;Fisher, Jeffrey S.;Lee, Abraham P.
通讯作者：
Lee, Abraham P.