Atherogenesis, calcium and calcium antagonists.
Atherogenesis, calcium and calcium antagonists.
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动脉粥样硬化、钙和钙拮抗剂。
DOI：
10.1016/0002-9149(90)91256-6
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
P. D. Henry
中科院分区：
文献类型：
--
作者：
P. D. Henry
Hyperchotesterolemia and arterial hypertension are highly interrelated risk factors of atherosclerosis. Early lesions in nonhuman primates with dietary hyperchotesterolemia resemble atherosclerotic lesions demonstrable in the arteries of American children with comparably elevated plasma cholesterol levels. Lesion formation depends upon calcium-regulated cellular processes such as chemotaxis, adhesion, migration, proliferation, lipid uptake and necrosis. Interventions acting on cell calcium uptake including treatment with calcium chelating agents, lanthanum trichloride, and calcium antagonists may retard atherogenesis in fat-fed animals in the absence of hypolipidemic effects. Recent controlled coronary angiographic trials in patients with coronary artery disease suggest that calcium antagonists may retard the progression of coronary atherosclerosis in humans. Large-scale long-term studies are needed to determine the utility of these agents for the treatment of coronary artery disease.
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DOI：
10.1161/01.atv.10.2.164
发表时间：
1990-03-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
MASUDA, J;ROSS, R
通讯作者：
ROSS, R
硝苯地平可增加富含脂质的兔动脉平滑肌细胞中胆固醇酯的水解活性。
DOI：
10.1172/jci111860
发表时间：
1985
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Etingin,OR;Hajjar,DP
通讯作者：
Hajjar,DP
洞察白人的凶兆：冠状动脉疾病——博加卢萨心脏研究。
DOI：
10.1016/0002-9149(89)90681-4
发表时间：
1989
期刊：
The American journal of cardiology
影响因子：
--
作者：
Berenson,GS;Srinivasan,SR;Wattigney,W;Webber,LS;Newman3rd,WP;Tracy,RE
通讯作者：
Tracy,RE
影响因子：
4.6
作者：
Anderson,HC
通讯作者：
Anderson,HC