Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.
Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures.
复制标题
小鼠 (MFH-1) 和人类 (FKHL 14) 间充质叉头 1 基因的分离揭示了它们基因和蛋白质结构的保守性。
作者：
N. Miura;K. Iida;H. Kakinuma;X. L. Yang;T. Sugiyama
The very recently found evolutionarily conserved DNA-binding domain of 100 amino acids, termed the fork head domain, emerged from a sequence comparison of the rat hepatocyte transcription factor HNF-3 alpha and the homeotic gene fork head of Drosophila. We previously isolated a new member of this family, the mesenchyme fork head-1 (MFH-1) gene, which is expressed in developing mesenchyme. Here we describe the isolation of the mouse (MFH-1) and human (FKHL14) chromosomal MFH-1 genes and the determination of the gene and protein structures of MFH-1. We found that the MFH-1 gene has no introns and that the identity of the amino acid sequences of mouse and human MFH-1 proteins is 94%. We also investigated the transcriptional activity of the mouse and human MFH-1 proteins and found that both proteins act as positive transactivators.
登录
查看更多内容
肝细胞核因子 3/转录因子叉头翼螺旋家族八个成员的小鼠染色体位置。
影响因子：
4.4
作者：
Avraham,KB;Fletcher,C;Overdier,DG;Clevidence,DE;Lai,E;Costa,RH;Jenkins,NA;Copeland,NG
通讯作者：
Copeland,NG
影响因子：
4.6
作者：
S. Ang;A. Wierda;David J. Wong;K. Stevens;S. Cascio;J. Rossant;K. Zaret
通讯作者：
S. Ang;A. Wierda;David J. Wong;K. Stevens;S. Cascio;J. Rossant;K. Zaret
DOI：
10.1073/pnas.90.9.3948
发表时间：
1993-05-01
影响因子：
11.1
作者：
CLEVIDENCE, DE;OVERDIER, DG;COSTA, RH
通讯作者：
COSTA, RH
影响因子：
10.5
作者：
LAI, E;PREZIOSO, VR;DARNELL, JE
通讯作者：
DARNELL, JE
影响因子：
10.5
作者：
Hatini, V;Huh, SO;Lai, E
通讯作者：
Lai, E