Development of transmembrane signaling in the fetal rat Leydig cell.
Development of transmembrane signaling in the fetal rat Leydig cell.
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胎鼠 Leydig 细胞中跨膜信号传导的发展。
DOI：
10.1002/j.1939-4640.1989.tb00147.x
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发表时间：
1989
影响因子：
--
通讯作者：
Warren,DW
中科院分区：
文献类型：
--
作者：
Warren,DW
Gonadotropin binding to the adult Leydig cell activates a GTP binding protein that interacts with adenylate cyclase to increase cAMP production within the cell. The increased production of cAMP stimulates steroidogenesis and leads to an increase in testosterone production and secretion. The fetal Leydig cell responds to LH with an increase in cAMP and testosterone production as early as 15.5 days of gestation, although the specific mechanism of transmembrane signaling has not been characterized. Fetal rat testis cells from 13.5–20.5 days of gestation were treated with dibutyryl cAMP (dbcAMP), cholera toxin, and hCG to determine the onset of steroidogenesis stimulation by activation of each moiety in the transmembrane signaling system of the fetal Leydig cell. Maximal stimulation at each age from 14.5 through 20.5 days of gestation was achieved with 1 mM dbcAMP, 500 ng/ml cholera toxin, or 10 ng/ml hCG. At 13.5 days of gestation, fetal testes did not produce any testosterone. These findings indicate that a cholera toxin‐sensitive, stimulatory guanine‐nucleotide regulatory protein is functional in the fetal Leydig cell as early as 14.5 days of gestation. The LH receptor becomes functional in the transmembrane signaling system of the fetal Leydig cell at 14.5 days of gestation.
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脊髓早期部分逆转后小鸡后肢的运动神经元投射模式。
DOI：
10.1113/jphysiol.1980.sp013262
发表时间：
1980
期刊：
The Journal of Physiology
影响因子：
--
作者：
C. Lance‐Jones;L. Landmesser
通讯作者：
L. Landmesser
DOI：
--
发表时间：
1986
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
B. Mendelson
通讯作者：
B. Mendelson
斑马鱼毛特纳神经元的放射敏感性和起源时间。
影响因子：
2.7
作者：
C. Kimmel;S. Sessions;R. Kimmel
通讯作者：
R. Kimmel
非特异性机制的神经连接特异性？
影响因子：
15.9
作者：
G. Rager
通讯作者：
G. Rager
齿状回发育过程中可用突触位点占用的时间因素的证据。
影响因子：
2.9
作者：
David I. Gottlieb;W. Cowan
通讯作者：
W. Cowan