A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosus.
A controlled comparison of brachial artery flow mediated dilation (FMD) and digital pulse amplitude tonometry (PAT) in the assessment of endothelial function in systemic lupus erythematosus.
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DOI：
10.1177/0961203308096663
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发表时间：
2009-03
期刊：
影响因子：
2.6
通讯作者：
Gerhard-Herman MD
中科院分区：
文献类型：
--
作者：
Aizer J;Karlson EW;Chibnik LB;Costenbader KH;Post D;Liang MH;Gall V;Gerhard-Herman MD
血流介导性扩张(FMD)是血管内皮细胞功能的一种测量方法，其应用受到操作者依赖性的限制。脉冲幅度眼压计(PAT)是一种新的、对操作员依赖性较小的评估内皮功能的技术。这项研究比较了系统性红斑狼疮和对照组的PAT和FMD。30名系统性红斑狼疮患者和31名对照受试者入选。记录用药、心血管疾病和危险因素、SLE活动(SLAM-R)和损害(SLICC-DI)。同时进行FMD和PAT检查。硝酸甘油测定内皮非依赖性功能。平均年龄48.3±10.1岁，SLE病程16.2年，SLAM-R 8.3岁，SLICC-DI 1.0岁。大多数受试者的弗雷明翰风险评分为≤2%。SLE患者的FMD、PAT及硝酸甘油反应与对照组无明显差异。这项研究发现，在SLE或对照组中，FMD和PAT之间没有关联。在17例有雷诺氏病史的SLE患者中，FMD与PAT的相关性为0.50(P=0.04)。SLE患者的FMD或PAT评估的内皮功能与对照组无差异。除有雷诺氏病史的SLE患者外，FMD与PAT无相关性。内皮功能变异较大和心血管危险因素较多的人群中，FMD与PAT的相关性可能更强。
The utility of flow mediated dilation (FMD) a measure of endothelial function is limited by operator dependence. Pulse amplitude tonometry (PAT) is a novel, less operator-dependent technique to assess endothelial function. This study compares PAT to FMD in SLE and controls. Thirty women with SLE and 31 controls were enrolled. Medications, cardiovascular disease and risk factors, SLE activity (SLAM-R) and damage (SLICC-DI) were recorded. FMD and PAT were performed simultaneously. Endothelium-independent function was assessed with nitroglycerin. Average age was 48.3 ± 10.1 years, SLE duration 16.2 years, SLAM-R 8.3 and SLICC-DI 1.0. Framingham Risk Scores were ≤2% in most subjects. There were no differences between SLE cases and controls in FMD, PAT or response to nitroglycerin. This study found no association between FMD and PAT in SLE or controls. In the 17 SLE cases with a history of Raynaud’s, correlation between FMD and PAT was 0.50 (P = 0.04). There was no difference in endothelial function assessed by FMD or PAT in SLE cases versus controls. FMD did not correlate with PAT except in SLE cases with a history of Raynaud’s. Correlation between FMD and PAT may be stronger in populations with greater variation in endothelial function and more cardiovascular risk factors.
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