Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.
Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.
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DOI：
10.4049/jimmunol.1201916
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发表时间：
2012-11-15
期刊：
影响因子：
--
通讯作者：
Smiley ST
中科院分区：
文献类型：
--
作者：
Haynes L;Szaba FM;Eaton SM;Kummer LW;Lanthier PA;Petell AH;Duso DK;Luo D;Lin JS;Lefebvre JS;Randall TD;Johnson LL;Kohlmeier JE;Woodland DL;Smiley ST
在工业化世界，流感每年导致超过25万人死亡，在流感爆发期间，细菌感染经常导致继发性疾病，包括肺炎、支气管炎、鼻窦炎和中耳炎。在这里，我们证明了对不匹配的流感毒株的交叉反应免疫可以降低对继发性细菌感染的易感性，尽管这无法预防流感感染。具体地说，在攻击不匹配的H1N1流感之前感染H3N2流感的小鼠可以降低对革兰氏阳性肺炎链球菌或革兰氏阴性肺炎克雷伯菌的易感性。给小鼠接种高度保守的流感核蛋白也可以降低H1N1诱导的致死性细菌感染的敏感性。T细胞和抗体都有助于防御流感引起的细菌疾病；流感的交叉反应T细胞降低病毒滴度，而核蛋白抗体抑制肺部炎症的诱导。这些发现表明，在没有中和疫苗的情况下，未能预防流感感染的非中和流感疫苗仍可保护公众免受继发性细菌疾病的侵袭。
Influenza causes more than 250,000 deaths annually in the industrialized world and bacterial infections frequently cause secondary illnesses during influenza outbreaks, including pneumonia, bronchitis, sinusitis, and otitis media. Here we demonstrate that cross-reactive immunity to mismatched influenza strains can reduce susceptibility to secondary bacterial infections, even though this fails to prevent influenza infection. Specifically, infecting mice with H3N2 influenza before challenging with mismatched H1N1 influenza reduces susceptibility to either gram-positive Streptococcus pneumoniae or gram-negative Klebsiella pneumoniae. Vaccinating mice with the highly conserved nucleoprotein of influenza also reduces H1N1-induced susceptibility to lethal bacterial infections. Both T cells and antibodies contribute to defense against influenza-induced bacterial diseases; influenza cross-reactive T cells reduce viral titers, whereas antibodies to nucleoprotein suppress induction of inflammation in the lung. These findings suggest that non-neutralizing influenza vaccines that fail to prevent influenza infection may nevertheless protect the public from secondary bacterial diseases when neutralizing vaccines are not available.
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影响因子：
5.5
作者：
Lanthier, Paula A.;Huston, Gail E.;Moquin, Amy;Eaton, Sheri M.;Szaba, Frank M.;Kummer, Lawrence W.;Tighe, Micheal P.;Kohlmeier, Jacob E.;Blair, Patrick J.;Broderick, Michael;Smiley, Stephen T.;Haynes, Laura
通讯作者：
Haynes, Laura
DOI：
10.1136/bmj.b3928
发表时间：
2009-10-06
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Garcia-Garcia L;Valdespino-Gómez JL;Lazcano-Ponce E;Jimenez-Corona A;Higuera-Iglesias A;Cruz-Hervert P;Cano-Arellano B;Garcia-Anaya A;Ferreira-Guerrero E;Baez-Saldaña R;Ferreyra-Reyes L;Ponce-de-León-Rosales S;Alpuche-Aranda C;Rodriguez-López MH;Perez-Padilla R;Hernandez-Avila M
通讯作者：
Hernandez-Avila M
DOI：
10.1086/591708
发表时间：
2008-10-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Morens DM;Taubenberger JK;Fauci AS
通讯作者：
Fauci AS
影响因子：
4.4
作者：
Jelley-Gibbs, Dawn M.;Dibble, John P.;Swain, Susan L.
通讯作者：
Swain, Susan L.
影响因子：
6.4
作者：
ARMERDING, D;ROSSITER, H;LIEHL, E
通讯作者：
LIEHL, E