Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City.
Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City.
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DOI：
10.1136/bmj.b3928
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发表时间：
2009-10-06
期刊：
影响因子：
--
通讯作者：
Hernandez-Avila M
中科院分区：
文献类型：
--
作者：
Garcia-Garcia L;Valdespino-Gómez JL;Lazcano-Ponce E;Jimenez-Corona A;Higuera-Iglesias A;Cruz-Hervert P;Cano-Arellano B;Garcia-Anaya A;Ferreira-Guerrero E;Baez-Saldaña R;Ferreyra-Reyes L;Ponce-de-León-Rosales S;Alpuche-Aranda C;Rodriguez-López MH;Perez-Padilla R;Hernandez-Avila M
目的评价2008- 2009年墨西哥甲型H1N1流感流行期间季节性三价灭活疫苗与病例的关系。设计频率匹配的病例对照研究。2009年3月至5月，墨西哥城专科医院。参与者60名实验室确诊的甲型H1N1流感患者和180名其他疾病（非流感样疾病或肺炎）的对照者，居住在墨西哥城或墨西哥州，年龄和社会经济地位相匹配。主要结局指标：甲型H1N1流感三价灭活疫苗的优势比和有效性。结果病例入院、有创机械通气和死亡的可能性高于对照组。对照组比病例更有可能患有慢性疾病，从而导致流感相关并发症的风险更高。在多变量模型中，甲型H1N1流感与三价灭活疫苗（优势比0.27,95%可信区间0.11 ~ 0.66）和基础疾病（0.15,0.08 ~ 0.30）独立相关。疫苗有效性为73%（95%可信区间为34%至89%）。8例接种疫苗的病例无一死亡。初步证据表明，在墨西哥城流感流行期间，一家专科医院诊断出的2008- 2009年甲型H1N1大流行性流感三价灭活疫苗具有一定的保护作用，特别是严重形式的流感。
Objective To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico. Design Frequency matched case-control study. Setting Specialty hospital in Mexico City, March to May 2009. Participants 60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status. Main outcome measures Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1. Results Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73% (95% confidence interval 34% to 89%). None of the eight vaccinated cases died. Conclusions Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City.
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影响因子：
9.7
作者：
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