Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex
Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex
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急性缺血大鼠皮层侧支血流随局部血流分布的动态变化
DOI：
10.1117/1.jbo.17.12.125001
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发表时间：
2012-12
影响因子：
3.5
通讯作者：
Qingming Luo
中科院分区：
文献类型：
--
作者：
Zhen Wang;Weihua Luo;Fangyuan Zhou;Pengcheng Li;Qingming Luo
抽象的。脑血流量 (CBF) 通过保证大脑持续的氧气和葡萄糖供应，对于维持大脑功能至关重要。一旦缺血性中风期间主要血管闭塞，侧支通道 (CC) 就会被招募来为缺血区域提供 CBF 的替代方案。然而，对侧枝血流动态演变与局部血流分布之间关系的了解仍然有限。在这项研究中，激光散斑成像用于评估永久性大脑中动脉闭塞（MCAo）大鼠皮质中CC和局部血流的动态变化。我们发现，MCAo 后 CC 立即向缺血区域提供血流。更重要的是，急性脑卒中期间CC存在三种动态变化：持续性CC、非永久性CC和短暂性CC，分别与局部血流的不同分布有关。尽管缺血期间可能发生梗死周围去极化(PID)，但有和没有PID的大鼠之间CC的发生时间和持续时间没有明显意义。这些结果表明，CC的最初出现并不能确保其持续存在，而且急性缺血性卒中的侧支血流可能会随着局部血流的分布而变化，这可能有助于理解侧支征募并促进未来侧支治疗的发展。
Abstract. Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, there was no obvious significance about the onset time and duration of CCs between rats with and without PID. These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future.
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