N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
复制标题
DOI：
10.1021/ja400021x
复制
发表时间：
2013-07-10
影响因子：
15
通讯作者：
Nathan, Carl
中科院分区：
文献类型：
--
作者：
Lin, Gang;Chidawanyika, Tamutenda;Tsu, Christopher;Warrier, Thulasi;Vaubourgeix, Julien;Blackburn, Christopher;Gigstad, Kenneth;Sintchak, Michael;Dick, Lawrence;Nathan, Carl
We identified N,C-capped dipeptides that are selective for the Mycobacterium tuberculosis proteasome over human constitutive and immunoproteasomes. Differences in S3 and S1 binding pockets appeared to account for species-selectivity. The inhibitors are able to penetrate mycobacteria and kill non-replicating M. tuberculosis under nitrosative stress.
登录
查看更多内容
影响因子：
6.7
作者：
Gandotra S;Lebron MB;Ehrt S
通讯作者：
Ehrt S
影响因子：
56.9
作者：
Darwin, KH;Ehrt, S;Nathan, CF
通讯作者：
Nathan, CF
影响因子：
82.9
作者：
Gandotra, Sheetal;Schnappinger, Dirk;Ehrt, Sabine
通讯作者：
Ehrt, Sabine
影响因子：
30.5
作者：
Kincaid, Eleanor Z.;Che, Jenny W.;York, Ian;Escobar, Hernando;Reyes-Vargas, Eduardo;Delgado, Julio C.;Welsh, Raymond M.;Karow, Margaret L.;Murphy, Andrew J.;Valenzuela, David M.;Yancopoulos, George D.;Rock, Kenneth L.
通讯作者：
Rock, Kenneth L.
影响因子：
30.3
作者：
Bryk, Ruslana;Gold, Benjamin;Nathan, Carl
通讯作者：
Nathan, Carl