Inference of genetic networks using neural network models
Inference of genetic networks using neural network models
复制标题
使用神经网络模型进行遗传网络推理
DOI:
--
复制
发表时间:
2005
期刊:
影响因子:
--
通讯作者:
Mariko Okada
中科院分区:
文献类型:
--
作者:
Shuhei Kimura;Katsuki Sonoda;S. Yamane;Koki Matsumura;Mariko Okada
We propose a new method for the inference of the genetic networks. The proposed method uses a neural network model to describe the genetic network. The inference of the neural network model of the genetic network is defined as the function optimization problem. As the function optimizer for this problem, a genetic local search is used. At this time, to enhance the probability of finding a reasonable solution, we introduce a priori knowledge about the genetic network into the objective function. In this paper, we also propose the method based on the sensitivity analysis to interpret the optimized neural network model. Through artificial genetic network inference problems, we verify the effectiveness of the proposed method.
DOI:
--
发表时间:
1992
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Shiraishi,F;Savageau,MA
通讯作者:
Savageau,MA
影响因子:
56.9
作者:
DeRisi, JL;Iyer, VR;Brown, PO
通讯作者:
Brown, PO