Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia.
Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia.
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DOI：
10.1016/j.actatropica.2009.11.005
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发表时间：
2010-04
期刊：
影响因子：
2.7
通讯作者：
Herrera, Socrates
中科院分区：
文献类型：
--
作者：
Caicedo, Olga;Villamor, Eduardo;Forero, Yibby;Ziade, Jose;Perez, Pilar;Quinones, Francisco;Arevalo-Herrera, Myriam;Herrera, Socrates
贫血是人类疟疾的常见并发症。由于微量营养素缺乏症在疟疾流行地区非常普遍，似乎有助于贫血的病因，我们在哥伦比亚的图马科进行了一项横断面研究，以研究96名主要患有恶性疟原虫疟疾的成年人血浆维生素B12或红细胞叶酸浓度与血红蛋白（Hb）之间的关系。叶酸和维生素B12缺乏的患病率分别为26.0%和26.6%。叶酸和血红蛋白浓度之间呈负线性关系。最低和最高叶酸四分位数之间的Hb校正差异为1 g/dL（p = 0.04; p，趋势检验= 0.01）。维生素B12与血红蛋白浓度无关，也没有改变叶酸和血红蛋白之间的关系。顺便说一句，体重指数（BMI）与寄生虫血症和临床疟疾的风险呈负相关。未来的纵向研究是必要的，以确定潜在的病理生理作用，叶酸在疟疾相关的贫血。
Anemia is a common complication of human malaria. Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly Plasmodium falciparum malaria. Prevalence of folate and vitamin B12 deficiencies were 26.0% and 26.6%, respectively. There was an inverse, linear relation between folate and Hb concentrations. Adjusted difference in Hb between lowest and highest folate quartiles was 1 g/dL (p = 0.04; p, test for trend = 0.01). Vitamin B12 was not associated with Hb concentrations and did not modify the associations between folate and Hb. Incidentally, body mass index (BMI) was inversely associated with parasitemia and risk of clinical malaria. Future longitudinal studies are warranted to determine the potential pathophysiological role of folate in malaria-related anemia.
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影响因子：
7.1
作者：
Savaria Morris, Martha;Jacques, Paul F.;Selhub, Jacob
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影响因子：
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DOI：
10.1590/s1020-49892005000600005
发表时间：
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影响因子：
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