Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer.
Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer.
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DOI：
10.1038/bjc.1998.688
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发表时间：
1998-11
影响因子：
8.8
通讯作者：
Imamura, M
中科院分区：
文献类型：
--
作者：
Ishigami, SI;Arii, S;Furutani, M;Niwano, M;Harada, T;Mizumoto, M;Mori, A;Onodera, H;Imamura, M
关键词：
血管内皮生长因子（VEGF）可能影响癌细胞的表型，如生长速度和转移潜能，这是由于其可能的多功能性质，包括对血管内皮细胞的促有丝分裂活性。本研究旨在探讨VEGF mRNA表达与大肠癌进展和转移的关系。采用北方印迹杂交法检测60例原发性结直肠癌患者癌组织和非癌组织中VEGF mRNA的表达水平。前者与后者的比值被定义为VEGF T/N比值，并评估了该比值在手术后的预后意义，以及与进展和转移潜力的关系。VEGF T/N值与肿瘤浸润深度（P=0.046）、肝转移（P < 0.0001）和淋巴结转移（P=0.036）显著相关。采用Kaplan-Meier法和log-rank检验估计患者预后。当VEGF T/N比高于4.8时，对数秩检验的卡方值最大，肿瘤被定义为显示VEGF mRNA的过表达。VEGFmRNA过表达的患者生存率明显低于VEGFmRNA未过表达的患者（P < 0.001）。根据多变量分析，VEGF mRNA过表达患者死亡的总体估计风险比为1.94（P=0.005）。因此，VEGF与结直肠癌的进展、侵袭和转移相关，并且认为原发肿瘤中VEGF mRNA的过表达与结直肠癌患者的不良预后密切相关。此外，VEGF T/N比值可作为结直肠癌患者独立的预后指标。
Vascular endothelial growth factor (VEGF) may affect the phenotype of cancer cells, such as growth velocity and metastatic potential, due to its probable multifunctional property including a mitogenic activity for vascular endothelial cells. The present study was designed to investigate the association of VEGF mRNA expression with progression and metastasis of human colorectal cancer. The level of VEGF mRNA expression was quantified by Northern blot hybridization in tumorous and non-tumorous tissues obtained from 60 primary colorectal cancer patients. The ratio of the former to the latter was defined as the VEGF T/N ratio, and the prognostic significance of this ratio, following surgery, in addition to the relationship to progression and metastatic potential, was evaluated. The value of the VEGF T/N ratio was significantly correlated with the depth of tumour infiltration (P=0.046), the incidence of liver metastasis (P < 0.0001) and lymph node metastasis (P=0.036). Patient prognosis was estimated by the Kaplan-Meier method and the log-rank test. When the VEGF T/N ratio was higher than 4.8 for which the chi2 value of the log-rank test was maximal, the tumour was defined as showing overexpression of VEGF mRNA. Patients with overexpression of VEGF mRNA demonstrated poorer survival than patients without overexpression of VEGF mRNA (P < 0.001). The overall estimated hazard ratio for death in patients with overexpression of VEGF mRNA was 1.94 according to a multivariate analysis (P=0.005). Thus, VEGF is associated with the progression, invasion and metastasis of colorectal cancer, and overexpression of VEGF mRNA in the primary tumour is assumed to be closely correlated with poor prognosis in colorectal cancer patients. Moreover, the VEGF T/N ratio may be used as an independent prognostic marker in colorectal cancer patients.
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影响因子：
15.9
作者：
FERRARA, N;WINER, J;LEVINSON, AD
通讯作者：
LEVINSON, AD
影响因子：
4.8
作者：
LI, J;PERRELLA, MA;LEE, ME
通讯作者：
LEE, ME
影响因子：
4.8
作者：
MANDRIOTA, SJ;SEGHEZZI, G;PEPPER, MS
通讯作者：
PEPPER, MS
DOI：
10.1016/0006-291x(91)91276-i
发表时间：
1991-12-16
影响因子：
3.1
作者：
PEPPER, MS;FERRARA, N;MONTESANO, R
通讯作者：
MONTESANO, R
影响因子：
56.9
作者：
SENGER, DR;GALLI, SJ;DVORAK, HF
通讯作者：
DVORAK, HF