AMPK at the nexus of energetics and aging.
AMPK at the nexus of energetics and aging.
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DOI：
10.1016/j.cmet.2014.03.002
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发表时间：
2014-07-01
期刊：
影响因子：
29
通讯作者：
Mair WB
中科院分区：
文献类型：
--
作者：
Burkewitz K;Zhang Y;Mair WB
When energy supply is low, organisms respond by slowing aging and increasing resistance to diverse age-related pathologies. Targeting the mechanisms underpinning this response may therefore treat multiple disorders through a single intervention. Here we discuss AMP-activated protein kinase (AMPK) as an integrator and mediator of several pathways and processes linking energetics to longevity. Activated by low energy, AMPK is both pro-longevity and druggable, but its role in some pathologies may not be beneficial. As such, activating AMPK may modulate multiple longevity pathways to promote healthy aging, but unlocking its full potential may require selective targeting towards substrates involved in longevity-assurance.
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DOI：
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发表时间：
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期刊：
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影响因子：
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通讯作者：
Gems, David