Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study.
Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study.
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DOI：
10.1186/1471-2407-8-322
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发表时间：
2008-11-06
期刊：
影响因子：
3.8
通讯作者：
Weiderpass, Elisabete
中科院分区：
文献类型：
--
作者：
Wedren, Sara;Lovmar, Lovisa;Humphreys, Keith;Magnusson, Cecilia;Melhus, Hakan;Syvanen, Ann-Christine;Kindmark, Andreas;Landegren, Ulf;Fermer, Maria Lagerstrom;Stiger, Fredrik;Persson, Ingemar;Baron, John A.;Weiderpass, Elisabete
Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen receptor alpha gene (ESR1) is associated with endometrial cancer risk. In 702 cases with invasive endometrial cancer and 1563 controls, we genotyped five markers in ESR1 and used logistic regression models to estimate odds ratios (OR) and 95 percent confidence intervals (CI). We found an association between rs2234670, rs2234693, as well as rs9340799, markers in strong linkage disequilibrium (LD), and endometrial cancer risk. The association with rs9340799 was the strongest, OR 0.75 (CI 0.60–0.93) for heterozygous and OR 0.53 (CI 0.37–0.77) for homozygous rare compared to those homozygous for the most common allele. Haplotype models did not fit better to the data than single marker models. We found that intronic variation in ESR1 was associated with endometrial cancer risk.
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DOI：
10.1186/bcr811
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Wedrén S;Lovmar L;Humphreys K;Magnusson C;Melhus H;Syvänen AC;Kindmark A;Landegren U;Fermér ML;Stiger F;Persson I;Baron J;Weiderpass E
通讯作者：
Weiderpass E
影响因子：
10.3
作者：
ROODI, N;BAILEY, LR;PARL, FF
通讯作者：
PARL, FF
DOI：
10.1016/0960-0760(92)90214-4
发表时间：
1992-09-01
影响因子：
4.1
作者：
MCGUIRE, WL;CHAMNESS, GC;FUQUA, SAW
通讯作者：
FUQUA, SAW
影响因子：
6.1
作者：
Stavrou, I;Zois, C;Tsatsoulis, A
通讯作者：
Tsatsoulis, A
影响因子：
9.8
作者：
Cordell, HJ;Clayton, DG
通讯作者：
Clayton, DG