Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severity.
Chlamydia trachomatis strains and virulence: rethinking links to infection prevalence and disease severity.
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DOI：
10.1086/652398
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
Byrne GI
中科院分区：
文献类型：
--
作者：
Byrne GI
考虑到沙眼衣原体生殖器感染的流行率和疾病严重性，一个悬而未决的问题是，更流行的菌株或更有可能导致严重疾病并发症的菌株是否与特定的毒力属性有因果关系。区分衣原体菌株的主要方法是根据主要外膜蛋白(MOMP)的差异。MOMP血清型的一个子集(D，E)很容易成为世界上最流行的毒株，但MOMP血清型和基因组分析并没有产生一致的毒力依赖于菌株的差异。需要将衣原体菌株的定义扩展到MOMP范式之外，以更好地了解这种病原体的毒力特性以及这些特性如何反映疾病的严重性。与沙眼或性传播疾病(STD)相关的两种主要沙眼衣原体致病生物型已经出现了实质性的遗传和表型差异，但STD组内的差异并未产生可靠的疾病严重程度属性。许多候选毒力因子已被确定，包括多态的外膜自转运蛋白家族，推测的大细胞毒素，3型分泌效应物，胁迫反应蛋白和由隐质粒产生的蛋白质或其他调节因子。需要继续开发衣原体基因转移系统，并将基因组方法应用于大量临床分离株，以明确地将关键的衣原体毒力因子与流行率和疾病严重程度联系起来。
An unanswered question in consideration of prevalence and disease severity for Chlamydia trachomatis genital infections is whether more prevalent strains or strains more likely to cause serious disease complications are causally associated with specific virulence attributes. The major method for distinguishing chlamydial strains is based on differences in the major outer membrane protein (MOMP). A sub-set of MOMP serovars (D,E) are easily the most prevalent strains identified worldwide, but MOMP serovar and genovar analyses have not yielded consistent strain-dependent virulence distinctions. Expansion of the definitions of chlamydial strains beyond the MOMP paradigm are needed to better understand virulence properties for this pathogen and how these properties reflect disease severity. Substantive genetic and phenotypic differences have emerged for the two major C. trachomatis pathobiotypes associated with either trachoma or sexually transmitted diseases (STDs), but differences within the STD group have not yielded reliable disease severity attributes. A number of candidate virulence factors have been identified, including the polymorphic outer membrane autotransporter family of proteins, the putative large cytotoxin, type three secretion effectors, stress response proteins and proteins or other regulatory factors produced by the cryptic plasmid. Continued work on the development of a chlamydial gene transfer system and application of genomic approaches to large collections of clinical isolates will be required to associate key chlamydial virulence factors with prevalence and disease severity in a definitive way.
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影响因子：
3.6
作者：
Fields, KA;Hackstadt, T
通讯作者：
Hackstadt, T
影响因子：
3
作者：
Erridge, C;Pridmore, A;Poxton, IR
通讯作者：
Poxton, IR
影响因子：
3.1
作者：
Brunelle, BW;Sensabaugh, GF
通讯作者：
Sensabaugh, GF
DOI：
10.1099/00221287-139-5-1083
发表时间：
1993-05-01
期刊：
JOURNAL OF GENERAL MICROBIOLOGY
影响因子：
--
作者：
COMANDUCCI, M;CEVENINI, R;RATTI, G
通讯作者：
RATTI, G
影响因子：
7
作者：
Gomes, Joao P.;Bruno, William J.;Dean, Deborah
通讯作者：
Dean, Deborah