Current understanding of the human microbiome.
Current understanding of the human microbiome.
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DOI：
10.1038/nm.4517
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发表时间：
2018-04-10
期刊：
影响因子：
82.9
通讯作者：
Knight R
中科院分区：
文献类型：
--
作者：
Gilbert JA;Blaser MJ;Caporaso JG;Jansson JK;Lynch SV;Knight R
Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes, and mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this Review, we focus on studies in humans to describe these challenges, and propose strategies that leverage existing knowledge to move rapidly from correlation to causation, and ultimately to translation.
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影响因子：
16.6
作者：
Durack J;Kimes NE;Lin DL;Rauch M;McKean M;McCauley K;Panzer AR;Mar JS;Cabana MD;Lynch SV
通讯作者：
Lynch SV
影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
12.3
作者：
Debelius J;Song SJ;Vazquez-Baeza Y;Xu ZZ;Gonzalez A;Knight R
通讯作者：
Knight R
DOI：
10.1073/pnas.1000162107
发表时间：
2010-04-06
影响因子：
11.1
作者：
Fierer, Noah;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob