Temporal dynamics of the human vaginal microbiota.
Temporal dynamics of the human vaginal microbiota.
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DOI：
10.1126/scitranslmed.3003605
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发表时间：
2012-05-02
影响因子：
17.1
通讯作者：
Ravel J
中科院分区：
文献类型：
--
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
阐明影响阴道细菌群落稳定性的因素可能有助于预测影响妇女健康的疾病风险。在这里，我们描述了时间动态的阴道细菌群落的组成在32个育龄妇女超过16周的时间。分析揭示了五个主要类别的细菌群落的动态，并表明，一些社区在短时间内发生显着变化，而另一些则相对稳定。使用新的定量措施模拟社区稳定性表明，偏离稳定性与月经周期，细菌群落组成和性活动的时间相关。所研究的妇女都是健康的，因此看来，无论是群落组成本身的变化，还是观察到的更高水平的多样性（共显性），都不一定表明生态失调，其中微生物失衡伴随着症状。
Elucidating the factors that impinge on the stability of bacterial communities in the vagina may help in predicting the risk of diseases that affect women’s health. Here, we describe the temporal dynamics of the composition of vaginal bacterial communities in 32 reproductive age women over a 16-week period. The analysis revealed the dynamics of five major classes of bacterial communities and showed that some communities change markedly over short time periods, whereas others are relatively stable. Modeling community stability using new quantitative measures indicates that deviation from stability correlates with time in the menstrual cycle, bacterial community composition and sexual activity. The women studied are healthy, thus it appears that neither variation in community composition per se, nor higher levels of observed diversity (co-dominance) are necessarily indicative of dysbiosis, in which there is microbial imbalance accompanied by symptoms.
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影响因子：
3.1
作者：
Marrazzo JM;Martin DH;Watts DH;Schulte J;Sobel JD;Hillier SL;Deal C;Fredricks DN
通讯作者：
Fredricks DN
影响因子：
9.4
作者：
Forney, Larry J.;Gajer, Pawel;Ravel, Jacques
通讯作者：
Ravel, Jacques
影响因子：
3.1
作者：
Fredricks, David N;Marrazzo, Jeanne M
通讯作者：
Marrazzo, Jeanne M
DOI：
10.1016/j.bpobgyn.2006.12.004
发表时间：
2007-06-01
影响因子：
5.5
作者：
Witkin, Steven S.;Linhares, Iara Moreno;Giraldo, Paulo
通讯作者：
Giraldo, Paulo
影响因子：
158.5
作者：
Hillier, SL;Nugent, RP;Klebanoff, MA
通讯作者：
Klebanoff, MA